Network Analysis of Skeletal Muscle During Spaceflight in Male Mice

76% of the whole mouse genome. Of these, 840 genes met the t-test criteria, p<0.05. Canonical networks linked to EIF2 signaling, calcium ion signaling, and oxidative stress response were significantly enriched by the differentially expressed genes. A comprehensive energy deprivation was indicated as functions related to protein synthesis and degradation, lipid synthesis and oxidation, and ATP hydrolysis were inhibited, and mitochondrial dysfunction was activated.<br />Conclusions: This is the first time that skeletal muscle changes have been studied in male mice during spaceflight, and these data add important new findings to changes that occur to the musculoskeletal system in male mice during spaceflight. In orthopaedic trauma, many patients spend prolonged periods non-weight bearing and can experience significant muscle atrophy as a result. The networks analyzed in this work may prove to be targets for future therapies to counter this atrophy.

Creator

• Sowe, Bintu
• Savaglio, Michael
• Hammamieh, Rasha
• Waning, David
• Chakraborty, Nabarun
• Childress, Paul
• Kumar, Raina
• Dimitrov, George
• Kacena, Melissa
• Gautam, Aarti

Language

• English

Date created

• 11/9/2018

Resource type

• presentation

Source

• mucom_rd_106

Rights statement

• http://rightsstatements.org/vocab/InC/1.0/