Effect of Cutaneous Local Axon Reflexes, Perfusion Pressure, and Ischemia on Exogenous Cholinergic-Induced Eccrine Sweating in Humans

30 cm from heart level; CVAR), venoarteriolar response plus a decrease in perfusion pressure (venous occlusion by proximal cuff inflation; CVAR with DPP), and ischemia (arterial occlusion by proximal cuff inflation) and sweat rate was measured by perfusing anhydrous medical air through a ventilated capsule (capacitance hygrometry). Decreased SkBF was observed with CVAR (58±10, 59±4, and 63±8%), CVAR with DPP (30±13, 22±14 and 37±3%), and ischemia (98±1, 100±2 and 91±3% for the pilocarpine ED₅₀, pilocarpine E_MAX, and vehicle control, respectively). Despite these significant decreases in SkBF, changes in eccrine sweat rate were minimal (CVAR = 5±5, 9±4, and 8±6%; CVAR with DPP = 6±8, 1±5, and 7±6%; and ischemia = 5±7, 5±4, and 6±5% for the pilocarpine ED₅₀, pilocarpine E_MAX, and vehicle control, respectively). These preliminary data suggest that acute decreases in SkBF do not proportionally decrease cholinergic-induced sweating in human forearm skin. One interpretation of this is independent control and regulation of cutaneous blood vessels and eccrine sweat glands in humans.

Creator

• Alibegovic, Kenan
• Daggett, James
• Narra, Seetharam
• Wilson, Thad
• Metzler-Wilson, Kristen
• Kocherlakota, Uma
• Fang, Milie

Language

• English

Palabra Clave

• eccrine sweat glands
• skin sympathetic nerve activity
• regulation of cutaneous blood vessels
• Human skin blood flow (SkBF)

Date created

• 11/10/2017

Resource type

• poster

Source

• mucom_rd_51

Rights statement

• http://rightsstatements.org/vocab/InC/1.0/