Role of CaMKK2 in Mechanical Stimulation of Bone

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MLA citation style (9th ed.)

Patel, Sheel, et al. Role of Camkk2 In Mechanical Stimulation of Bone. . 2021. marian.palni-palci-staging.notch8.cloud/concern/generic_works/a415e73b-0cae-410a-8181-84c4201e5907?locale=it.

APA citation style (7th ed.)

P. Sheel, B. Margaret, W. Adam, S. Uma, R. Alexander, T. William, S. Jennifer, B. Teresita, & W. Justin. (2021). Role of CaMKK2 in Mechanical Stimulation of Bone. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/a415e73b-0cae-410a-8181-84c4201e5907?locale=it

Chicago citation style (CMOS 17, author-date)

Patel, Sheel, Bello, Margaret , Warrick, Adam , Sankar, Uma, Robling, Alexander , Thompson, William, Shutter, Jennifer et al. Role of Camkk2 In Mechanical Stimulation of Bone. 2021. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/a415e73b-0cae-410a-8181-84c4201e5907?locale=it.

Note: These citations are programmatically generated and may be incomplete.

There is a need for anabolic therapies to treat degenerative bone diseases. Mechanical loading stimulates anabolic and inhibits catabolic pathways of bone leading to increased bone formation. Osteocytes are the bone cell type responsible for coordinating the mechano-stimulatory pathways in bone. Calcium/ calmodulindependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase with roles in bone remodeling. CaMKK2 global deletion results in lower osteoclast differentiation and higher osteoblast formation and activity.

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