Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

Doci, Colleen L.; Gutkind, J. Silvio

Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

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MLA citation style (9th ed.)

Doci, Colleen L, and Gutkind, J. Silvio. Targeting the Pi3 K-mtor Signaling Circuitry In Hpv-associated Oral Malignancies: Novel Precision Molecular Therapies. Springer. 2015. marian.palni-palci-staging.notch8.cloud/concern/generic_works/a3fd3857-dce1-47b1-95fa-b01c27e432fe?locale=en.

APA citation style (7th ed.)

D. C. L, & G. J. Silvio. (2015). Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/a3fd3857-dce1-47b1-95fa-b01c27e432fe?locale=en

Chicago citation style (CMOS 17, author-date)

Doci, Colleen L., and Gutkind, J. Silvio. Targeting the Pi3 K-Mtor Signaling Circuitry In Hpv-Associated Oral Malignancies: Novel Precision Molecular Therapies. Springer. 2015. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/a3fd3857-dce1-47b1-95fa-b01c27e432fe?locale=en.

Note: These citations are programmatically generated and may be incomplete.

HPV is the most common sexually transmitted infection and it is predicted that up to 80 % of Americans will have HPV infections in their lifetime. The etiology of cervical cancer has long been linked with persistent HPV infection, but the correlation between HPV and other cancer types, including head and neck squamous cell carcinomas (HNSCC), oropharyngeal carcinomas (OPCs), anal carcinomas, and cancers of the genital tract is emerging (Forman et al. Compared to alcohol- and tobacco-related HNSCC, HPV-associated head and neck cancer involves activation of specific molecular mechanisms, making HPV(+) HNSCCs diagnostically and therapeutically distinct. Here, we will review the current understanding of the molecular mechanisms in HPV(+) HNSCC with emphasis on the signaling events that drive the growth of HPV-associated HNSCC and the emerging opportunities for the development of novel precision molecular-targeted therapies for this disease.

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