Osilodrostat for the treatment of Cushing's disease

Introduction The treatment of Cushing’s disease (CD) has been advanced well with the introduction of treatment options like transsphenoidal surgery, radiosurgery, bilateral adrenalectomy, and various classes of medication; however, many patients still fail to achieve disease remission. Osilodrostat, an orally bioavailable adrenal steroidogenesis inhibitor, was approved in the USA and EU in 2020 for the treatment of CD. Areas covered This review provides an overview of Cushing’s disease and the newly FDA approved 11β-hydroxylase inhibitor, osilodrostat, for CD with a focus on pharmacodynamics, pharmacokinetics, safety and efficacy data, and phase 2 and 3 clinical trials. Expert opinion Osilodrostat has proven clinical efficacy and tolerability in phase 2 and 3 trials with CD patients who had an inadequate or reoccurring response to transsphenoidal surgery (TSS) and conventional first-line treatment. The phase 3 trial (LINC3) had 86% of the treatment group respond with normal urinary free cortisol (UFC) level compared to 29% in the placebo group (p < 0.001). Deemed as well-tolerated in all current pivotal trials, oral osilodrostat provides a noninvasive option for patients who cannot undergo surgery or patients who have reoccurring hypercortisolemia.

Creator

• Rasool, Syeda
• Skinner, Brian

Mitwirkende

• Hum, Julia

Publisher

• Taylor & Francis

Language

• English

Identifier

• https://doi.org/10.1080/14656566.2021.1897106

Stichwort

• osilodrostat
• steroidogenesis inhibitor
• hypercortisolism
• LCI699
• Cushing's Disease
• endocrinology

Date created

• 2021

Related URL

• From the publisher website:  https://www.tandfonline.com/doi/abs/10.1080/14656566.2021.1897106?journalCode=ieop20
• Available for request from the library catalog:  https://marianunivindianapolis.on.worldcat.org/v2/oclc/8942652670

Resource type

• Article

Source

• Expert Opinion on Pharmacotherapy (Vol.22, Iss.9)

Rights statement

• http://rightsstatements.org/vocab/InC/1.0/