The Role of GM-CSF in the Neuropathogenesis of Simian Immunodeficiency Virus (SIV)

Why do neurocognitive disorders persist in people living with HIV while taking combination antiretroviral therapy (cART)? • The brain is a known reservoir for HIV. • HIV can act on myeloid cell populations like macrophages. • Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a hematopoietic growth factor and type I soluble cytokine that has been demonstrated to have a proinflammatory role over macrophages (and other myeloid cells) and can induce proliferation and migration across the blood brain barrier (Vogel 2015). • GM-CSF has also been found to be present and is involved in the inflammation process of Simian Immunodeficiency Virus (SIV). • Along with GM-CSF, the expression of GM-CSF receptors has been shown to be increased in SIV. Hypothesis: In SIV infected regions of the midbrain, GM-CSF expression will be increased, which would contribute to the HIV neuropathogenesis by attracting inflammatory cells such as macrophages.

Creator

• Meckley, Rachael
• Delery, Elizabeth

Language

• English

Keyword

• HIV
• neurocognitive disorders
• Simian Immunodeficiency Virus

Date created

• 2021

Related URL

• Audio presentation:  https://marian.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=6ec5d908-de34-4833-8ac2-adf701234649

Resource type

• Poster

Rights statement

• http://rightsstatements.org/vocab/InC/1.0/