Muscle-derived factors influencing bone metabolism

Zysik, Victoria S.; Gries, Kevin; Jobe, Tyler K.; Leeds, Benjamin P.; Lowery, Jonathan W.; Griffin, Nicole

doi:10.1016/j.semcdb.2021.10.009

MLA citation style (9th ed.)

Zysik, Victoria S, et al. Muscle-derived Factors Influencing Bone Metabolism. Elsevier. 2022. marian.palni-palci-staging.notch8.cloud/concern/generic_works/1799ece6-2e8f-4aa4-b5d9-87a7f2e326e3?locale=it.

APA citation style (7th ed.)

Z. V. S, G. Kevin, J. T. K, L. B. P, L. J. W, & G. Nicole. (2022). Muscle-derived factors influencing bone metabolism. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/1799ece6-2e8f-4aa4-b5d9-87a7f2e326e3?locale=it

Chicago citation style (CMOS 17, author-date)

Zysik, Victoria S., Gries, Kevin, Jobe, Tyler K., Leeds, Benjamin P., Lowery, Jonathan W., and Griffin, Nicole. Muscle-Derived Factors Influencing Bone Metabolism. Elsevier. 2022. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/1799ece6-2e8f-4aa4-b5d9-87a7f2e326e3?locale=it.

Note: These citations are programmatically generated and may be incomplete.

A significant amount of attention has been brought to the endocrine-like function of skeletal muscle on various tissues, particularly with bone. Several lines of investigation indicate that the physiology of both bone and muscle systems may be regulated by a given stimulus, such as exercise, aging, and inactivity. Moreover, emerging evidence indicates that bone is heavily influenced by soluble factors derived from skeletal muscle (i.e., muscle-to-bone communication). The purpose of this review is to discuss the regulation of bone remodeling (formation and/or resorption) through skeletal muscle-derived cytokines (hereafter myokines) including the anti-inflammatory cytokine METRNL and pro-inflammatory cytokines (e.g., TNF-α, IL-6, FGF-2 and others). Our goal is to highlight possible therapeutic opportunities to improve muscle and bone health in aging.

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