The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan
PublicMLA citation style (9th ed.)
California Institute of Technology. 2023. marian.palni-palci-staging.notch8.cloud/concern/generic_works/1489dc00-f697-4a9f-84cd-eff5a8b70dd3?locale=en. The Impact of C. Elegans Ceramide Glucosyltransferase Enzymes On the Beneficial Effects of B. Subtilis Lifespan.APA citation style (7th ed.)
(2023). The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/1489dc00-f697-4a9f-84cd-eff5a8b70dd3?locale=enChicago citation style (CMOS 17, author-date)
The Impact of C. Elegans Ceramide Glucosyltransferase Enzymes On the Beneficial Effects of B. Subtilis Lifespan. California Institute of Technology. 2023. https://marian.palni-palci-staging.notch8.cloud/concern/generic_works/1489dc00-f697-4a9f-84cd-eff5a8b70dd3?locale=en.Note: These citations are programmatically generated and may be incomplete.
Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt block the beneficial effects of Bacillus subtilis on C. elegans lifespan. We found that loss of cgt-1 or cgt-3 reduces lifespan compared to wildtype worms, but did not prevent the lifespan-extending phenotype of B. subtilis. However, cgt-1(ok1045) and cgt-3(tm504) did play a minor role in blocking stress resistance of 5-day old worms treated with B. subtilis. Further studying CGTs may elucidate potential roles of glucosylceramides in host-bacterial interaction.
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