Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement

Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-cells themselves. Restoration of regulated insulin production is a predominant goal of translational diabetes research. Here, we provide a brief overview of recent advances in the fields of β-cell proliferation, regeneration, and replacement. The discovery of therapeutic targets and associated small molecules has been enabled by improved understanding of β-cell development and cell cycle regulation, as well as advanced high-throughput screening methodologies. Important findings in β-cell transdifferentiation, neogenesis, and stem cell differentiation have nucleated multiple promising therapeutic strategies. In particular, clinical trials are underway using in vitro–generated β-like cells from human pluripotent stem cells. Significant challenges remain for each of these strategies, but continued support for efforts in these research areas will be critical for the generation of distinct diabetes therapies.

Creator

• Goode, Roy A.
• Hum, Julia M.
• Kalwat, M.

Publisher

• Oxford University Press on behalf of the Endocrine Society

Language

• English

Identifier

• Doi: https://doi.org/10.1210/endocr/bqac193

关键词

• pancreatic islet beta cells
• induced pluripotent stem cells
• proliferation
• diabetes

Date created

• 2022

Related URL

• Available from the publisher:  https://academic.oup.com/endo/article-abstract/164/1/bqac193/6836713
• Available from the library catalog:  https://marianunivindianapolis.on.worldcat.org/oclc/9688508394

Resource type

• Article

Source

• Endocrinology (Vol. 164, No.1)

Rights statement

• http://rightsstatements.org/vocab/InC/1.0/