MU-COM Research Day

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Last Updated: 2021-10-22
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MU-COM Research Day is an annual showcase of the the research engagement of the students within the College of Osteopathic Medicine. Content on display are typically poster presentations along with faculty-led discussions of research projects. This event is coordinated by the MU-COM Research Club as well as the Faculty-led Research Club Committee.
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251.Two Views, or Not Two Views: That is the Question

Title Tesim:
Two Views, or Not Two Views: That is the Question
Creador:
Foster, Todd , Fischer, Thomas , and Orcutt, Michael
Related Url Tesim:
Audio presentation: https://marian.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=1dae4469-a30d-4c6f-8d61-adf70122f585
Descripción:
Traditionally, the acute wrist radiograph series is comprised of posteroanterior (PA), oblique, and lateral projections. There is controversy within the field of Orthopedics, however, over the value of the oblique view in determining a plan of care for a given fracture. An external survey of practicing Orthopedic Surgeons was conducted as a tool to quantify the clinical value of the oblique view radiograph in the setting of acute closed distal radius fractures, the most common fracture pattern in Americans.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
Poster
Palabra clave:
acute wrist fractures, Orthopedics, and radiograph
Fecha de Creacion:
2021

252.Type 2 Diabetes-Driven Alterations in Bone Healing and Angiogenesis

Title Tesim:
Type 2 Diabetes-Driven Alterations in Bone Healing and Angiogenesis
Creador:
Babu, Deepa, Blosser, Rachel, Awosanya, Olatundun, Randhave, Karishma, Evans-Molina, Carmella, Dadwal, Ushashi, Li, Jiliang, Bhatti, Fazal, Kacena, Melissa, Sun, Seungyup, Perugini, Anthony, Tersey, Sarah, and Orr, Kara
Descripción:
INTRODUCTION: Two out of five U.S. citizens born after 2014 are expected to develop type 2 diabetes (T2D). T2D patients are at increased risk for fracture and impaired fracture healing, including: increased frequency of partial union, delayed union, or nonunion. These outcomes can in part be explained by T2D-mediated physiological and structural changes in bone; most prominently, compromised microvascular performance, which negatively impacts angiogenesis necessary for bone regeneration. Currently, to enhance bone healing in nonunion, the only FDA-approved biological treatment is the use of bone morphogenetic protein-2 (BMP-2). However, BMP-2 does not always achieve union, has adverse side effects, and may not be optimal for overcoming the T2D-specific impairments to bone healing. OBJECTIVE: In this study, we aimed to characterize the mechanisms by which T2D impairs bone healing and hypothesize that this effect is mediated by impairments in angiogenesis and endothelial cell proliferation and function. METHODS: Using Tie2-CreER;Td-Tomato mice (Tie2CreERT+), we established a high fat diet (HFD)-induced T2D mouse model to compare with low fat diet (LFD)-fed mice. Mice underwent glucose tolerance testing, insulin tolerance testing, and echoMRI to confirm the T2D-like metabolic phenotype. They were then subjected to a femoral critical-size defect surgery and were treated with either saline or BMP-2. 60 mice were allocated to each diet and experimental treatment group. Healing of the defect was assessed by X-rays. Additionally, bone marrow-derived endothelial cells (BMECs) were collected from the surgically treated mice to assess changes in endothelial colony and tube formation in vitro. Statistical analyses were performed with a two-way ANOVA and a Tukey post-hoc test. All procedures completed were approved by the Indiana University School of Medicine Institutional Animal Care and Use Committee. RESULTS: Our results showed that after 12 weeks, HFD mice acquired a T2D-like metabolic phenotype. X-ray imaging revealed that fracture healing was impaired in the HFD mice, even with the administration of BMP-2. The isolation of BMECs was confirmed by visualization of fluorescent Tie2+ cells. Unexpectedly, in vitro tube formation assays indicated that HFD improved vessel-like formation properties. BMP-2 treatment appeared to improve some vessel-like formation properties compared to control treatment. CONCLUSIONS: Further data will need to be collected to better characterize differences in bone healing and to analyze angiogenesis in the healing femurs. Still, these data are significant as they reveal the mechanisms by which T2D impairs bone healing and demonstrate the important difference between examining endothelial cells in vitro vs. in vivo. Future investigations will examine if thrombopoietin, which our group has previously shown to improve both fracture healing and angiogenesis, may be a more effective treatment than BMP-2 in this model.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
presentation
Fecha de Creacion:
11/22/2019

253.Ultrasound-guided Great Saphenous Vein Access in Trauma Cases

Title Tesim:
Ultrasound-guided Great Saphenous Vein Access in Trauma Cases
Creador:
Roberts, Jessica, Roberts, Nathan, Dana, Gaston, and Erdini, Necla
Descripción:
The great saphenous vein (GSV) should be considered as a vascular access point in cases of difficult access such as in trauma patients or hypovolemic patients. The GSV has been proven to be a viable vessel for peripheral venous access, however its use in emergency departments (ED) is still limited nationally. Ultrasound guidance makes the GSV access procedure quick, easy, and accurate. Furthermore, with a handheld ultrasound machine, even first responders could be establishing access and providing life-saving fluids and medications in route to more substantial care.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
poster
Fecha de Creacion:
11/9/2018

254.Understanding Pennsylvania Tick Population and Tick-borne Disease Dynamics: A Retrospective Analysis of Archived Databases from 2008-2020

Title Tesim:
Understanding Pennsylvania Tick Population and Tick-borne Disease Dynamics: A Retrospective Analysis of Archived Databases from 2008-2020
Creador:
Sendatch, Julia, Lehman, Marcie, St. John, Heidi, Farris, Christina, Natalia, Nishi, Luce-Fedrow, Alison, and Stewart, Richard
Related Url Tesim:
Audio presentation: https://marian.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=b81fbc09-c852-4e7f-8a18-adf701232beb
Descripción:
Ticks have been widely studied for their importance in disease transmission. In Pennsylvania, four different ticks (associated with human diseases) are commonly encountered: (1) Dermacentor variabilis (Rocky Mountain Spotted Fever); (2) Ixodes scapularis (Lyme disease); (3) Amblyomma americanum (Ehrlichiosis); and (4) I. cookei (possible Powassan). In addition to the commonly occurring tick species,approximately 25 species have been identified in the state. I. scapularis, which was once primarily found in Central and Eastern PA, can now be found in all counties in PA. In recent years, PA has had the highest confirmed numbers of Lyme disease cases in the United States. The increasing abundance and prevalence of ticks known to vector human pathogens has prompted public health concerns and further research. Despite the devastating consequences, and potentially fatal outcomes of tick-borne diseases, the local/regional distribution of ticks in Pennsylvania is under-investigated with regards to changes in tick populations and tick-borne disease dynamics.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
Poster
Palabra clave:
Pennsylvania, Tick, Tick-borne Disease, and Retrospective Analysis
Fecha de Creacion:
2021

255.Urinary Complications After Omitting Bladder Catheterization During Atrial Fibrillation Ablation

Title Tesim:
Urinary Complications After Omitting Bladder Catheterization During Atrial Fibrillation Ablation
Creador:
Patel, Parin, Lehman, Andrew, and Ahmed, Asim
Descripción:
Context: Indwelling Urinary Catheterization (IUC) is among the most common procedures performed in the inpatient setting. Because there are risks associated with IUC, efforts to reduce its use when unnecessary should be made. Objective: Assess patient urinary and overall health outcomes after atrial fibrillation (Afib) ablation with and without IUC. Design: Retrospective cohort study of patients undergoing Afib ablation for paroxysmal atrial fibrillation between March 1 2017 and August 20 2018 at St Vincent Indianapolis Hospital. Setting: St Vincent Indianapolis is a tertiary referral center. All procedures were performed in the inpatient setting. All patients included in this study were over 18 years of age. The only exclusion criteria was for patients on dialysis at the time of procedure. Methods: Operative characteristics and patient identifying information were queried using Current Procedural Terminology (CPT) codes in the specified time frame. Patient characteristics and postop outcomes were assessed by manual chart review. Differences between patients who received IUC and patients who did not were assessed using Chi-Squared test for categorical data and Unpaired Student’s t-test for continuous data. Results: For our composite primary outcome of any urinary complication in the 7 days after procedure, 14 of 297 (4.71%) patients who underwent IUC developed complications, versus 0 of 92 who were not catheterized (P = 0.034). 1 patient developed urine retention, 3 were recatheterized, 6 developed UTI, 7 developed hematuria, 2 developed urethral pain, and 1 developed urethral trauma. Conclusions: Our study found a reduced rate of urinary complications after undergoing Afib ablation without IUC. Overall rates of complications were lower than expected. There is an ongoing randomized control trial investigating this same question that will ensure ascertainment of patient outcomes and reduce bias in patient assignment to treatment groups.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
poster
Fecha de Creacion:
11/9/2018

256.The Use of Direct-to-Consumer Genetic Testing in Evaluation of Genetic Disease Risk Perception

Title Tesim:
The Use of Direct-to-Consumer Genetic Testing in Evaluation of Genetic Disease Risk Perception
Creador:
Gardner, David and Scheeler, Alysha
Descripción:
Introduction: 23andMe provides consumers the opportunity to receive genetic information without involvement of a healthcare provider. As 23andMe continues to increase the number of variants and genetic diseases included in their health predisposition and carrier status reports, it is becoming apparent that direct-to-consumer genetic testing will play a role in the future of preventative medicine. Objective: The goal of this study is to gain knowledge of how participants interpret their own genetic information, their perceived risk of developing a genetic disease, and their perceived risk of passing a genetic disease to offspring. Methods: Thirty-two participants were sought to participate in the study. Participants were divided into four categories based on their experience in the biomedical sciences. A “gold standard” group composed of genetic counselors was used as a control. Partic-ipants were asked to complete 23andMe’s Health + Ancestry package. After reviewing their genetic results, participants completed a questionnaire analyzing how they interpreted their results and how they might use their results in the future. Results: Preliminary results demonstrate that most participants have a basic under-standing of genetic concepts and inheritance patterns of genetic disease. However, less comprehension of genetic reports was observed when participants were asked about specific genetic diseases and/or tested variants. Participants did not report a high level of concern for developing a genetic disease or passing a genetic disease to offspring and reported they do not plan to consult a genetic counselor about their results at this time. Further, participants reported high self-efficacy with interpreting their results. Conclusions: Preliminary findings demonstrate that while most participants under-stand basic genetic concepts and inheritance patterns, their comprehension of more detailed genetic concepts is lower when compared to genetic counselors. When combined with a high reported self-efficacy with the presented genetic information, participants may feel falsely-reassured by their results.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
poster
Fecha de Creacion:
11/22/2019

257.Using Palliative Leaders In Facilities to Transform care for Alzheimer’s Disease (UPLIFT-AD) – palliative care clinical trial in nursing homes

Title Tesim:
Using Palliative Leaders In Facilities to Transform care for Alzheimer’s Disease (UPLIFT-AD) – palliative care clinical trial in nursing homes
Creador:
Unroe, Kathleen and Equihua, Arthur
Related Url Tesim:
Audio presentation available: https://marian.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=ae1ad9e0-ea9a-4a8c-9df1-adf7011b699c
Descripción:
Nursing Homes (NH) often struggle to provide Palliative Care (PC) to their residents with Alzheimer’s and other Related Dementias (ADRDs). As a result, many NHs are searching for external PC consultants to help facilitate care within their facilities. Unfortunately, there are no clinical trials that provide examples of sustainable models of PC or their effectiveness in this population. Although, there is evidence that knowledge of or training in PC by NH staff can have benefits in patient care. The purpose of this study is to assess the effectiveness of the UPLIFT- PC implementation model in enhancing capacity of nursing homes to train in primary PC and improving the quality of life and quality of care for ADRD nursing home patients.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
Poster
Palabra clave:
Nursing Homes , Palliative Care, and Alzheimer’s Disease
Fecha de Creacion:
2021

258.Utility of a Scoring Tool for Living Kidney Donor Volunteers

Title Tesim:
Utility of a Scoring Tool for Living Kidney Donor Volunteers
Creador:
Lien, Savahanna, Wiley, Linda, Stepan, Rebecca, Voges, Margaret, Dunn, Ty, and Lecuyer-Koich, Anne
Descripción:
A comprehensive yet efficient evaluation of living kidney donor volunteers (LKDV) is key to a successful transplant program. Donor selection is complex and must balance donor medical suitability, compatibility issues and donor engagement. Identifying the most suitable donor when multiple volunteers are present can be difficult. Herein we examine the utility of a novel scoring tool in the early assessment of LKDVs. Methods: 13 donor and 5 recipient variables were scored (-5 to +5). Donor variables included relationship, blood type, motivation, psychosocial and medical comorbidities, substance use, distance from transplant center, financial concerns and interest in paired donation. Transplant candidate (recipient) variables included kidney function, active status, blood type and cPRA. Donor scores were analyzed in relation to evaluation metrics such as donor initiative, outcome of donor evaluation, and actual donation. Correlation of recipient scores with transplant and time until transplant were assessed. Results: From January-August 2015, the scoring tool was applied to all living donor volunteers(n=367) and their intended recipients(n=173). LDKVs with a higher score were more likely to complete preliminary testing(1.91vs1.41, p
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
poster
Palabra clave:
living kidney donor volunteers (LKDV) Donor variables and Transplant candidate (recipient) variables
Fecha de Creacion:
1/1/2015

259.Utility of Classroom Subject Performance Outcomes in Preparation for the Comprehensive Osteopathic Medical Licensing Examination (COMLEX)

Title Tesim:
Utility of Classroom Subject Performance Outcomes in Preparation for the Comprehensive Osteopathic Medical Licensing Examination (COMLEX)
Creador:
Zahl, Sarah and Chaudhari, Rachna
Related Url Tesim:
Audio presentation: https://marian.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=9c770705-c036-43d9-a2d9-adf70123615a
Descripción:
Correlations exist between undergraduate GPA, MCAT, and COMLEX-USA Level 1 scores as well as between course grades and overall COMLEX score (Wong et al. 2009 & Sefcik et al. 2003). • Longitudinal reports on ProgressIQ contain aggregate data over two years of didactic work in the first two years of medical school. Classroom subjects divided into systems report an average score over two years. • NBOME provides COMLEX-USA Level 1 score reports for each examiner which include discipline sub-scores for each system.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
Poster
Palabra clave:
Classroom Subject Performance Outcomes and COMLEX
Fecha de Creacion:
2021

260.What is OMT’s Effect on the Autonomic Nervous System?

Title Tesim:
What is OMT’s Effect on the Autonomic Nervous System?
Creador:
Waldherr, Alexander
Descripción:
Paraspinal inhibition is an osteopathic manipulative treatment (OMT) purported to work via the sympathetic nervous system and aid in restoring autonomic homeostasis. Despite clinical anecdotal evidence, the mechanism of action has not been robustly evaluated. This study tested the hypothesis that OMT acutely alters the autonomic nervous system (ANS) and that the effects of OMT would be more pronounced in excited states. Because direct measures of ANS are difficult to assess in human in vivo studies, static and dynamic measures of ANS-mediated end-organ responses were quantified. These included beat-by-beat heart rate, arterial blood pressure, arm and forehead skin blood flow, and stroke volume as well as calculations of systemic and cutaneous vascular resistance/conductance and cardiac output. To determine if the excited state modulates ANS effects or restores autonomic homeostasis, participants were tested in a resting supine position and a 60° head-up tilt. Head-up tilt was performed via a tilt table to reduce physiological adjustments associated with volitional standing. Nineteen apparently healthy (health history and vital sign assessment) individuals participated in this randomly assigned cross-over designed study. The protocol consisted of supine baseline, OMT, and recovery for one session then supine baseline, tilt baseline, tilt OMT, and supine recovery for the other. Each data segment was recorded for 6 minutes to allow for fast Fourier and transfer function analysis of beat-by-beat data. No differences were noted between variables when comparing the supine baselines, indicating baselines were similar for both trials. During neutral conditions OMT decreased the heart rate and increased stroke volume but did not alter the cardiac output or any other measured variable. Excitation was observed with head-up tilt as identified by a) increases in arterial blood pressure and heart rate, b) decreases in stroke volume and cutaneous vascular conductance, and c) no change in systemic vascular resistance and cardiac output. During sympathoexcitatory conditions no static differences were observed during OMT. Dynamic analysis of systolic blood pressure, R-to-R, and skin blood flow interval yielded some condition and treatment trends and effects in both the low and high frequency ranges. Low frequency ranges are often linked to sympathetic nervous system, while high frequency changes are often linked to the parasympathetic nervous system, or a combination of the two branches of the ANS. This may indicate that the ANS is being altered by OMT, but these control system changes are complex and not always manifested in static averages. Thus, studies involving OMT influences on the ANS and associated variables need to account for these complexities, especially with regard to background sympathetic tone, hemostasis, and neural reflexes when evaluating mechanisms of action and associated physiological effects.
Declaración de derechos:
http://rightsstatements.org/vocab/InC/1.0/
Idioma:
English
Tipo de recurso:
poster
Fecha de Creacion:
11/22/2019