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  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Creador:
    Eaton, Michael and Newby, Jordan
    Descripción:
    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
    Tipo de recurso:
    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Creador:
    Ward, Taylor
    Descripción:
    The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
    Tipo de recurso:
    poster

  • Investigating the HSF1-HSF2 Interaction

    Creador:
    Jaeger, Alex, Thiele, Dennis, and Wacker, Bryan
    Descripción:
    The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
    Tipo de recurso:
    poster

  • Assessing Patient Perspective of Diet and Exercise in Patients Taking Semaglutide: An Educational Intervention

    Coincidencias de palabras clave:
    ... enough to achieve long-term health benefits. Inclusion Criteria: 1) adult 18 years or older without ...
    ... glucagon-like-peptide (GLP-1) to combat the obesity and diabetic epidemic. Project: 21 days in length with ...
    ... two data collection periods. GLP-1 prompts the body to produce more insulin, reducing blood sugar ...
    ... (glucose). GLP-1 in higher amounts interacts with parts of the brain to suppress appetite and signal ...
    ... medical facility in Indianapolis, IN. Days 1-14: Patients were invited to participate in the project via ...
    Creador:
    Young, Alexis
    Descripción:
    The DNP project aimed to: assess the effectiveness of an educational intervention focused on improving patient knowledge and receptiveness of making necessary diet and exercise changes during their semaglutide treatment...
    Tipo de recurso:
    Poster

  • Disparities & Inequalities in Type 1 Diabetes

    Coincidencias de palabras clave:
    ... Disparities & Inequalities in Type 1 Diabetes By: Shehr Asghar Marian University College of ...
    ... Osteopathic Medicine MS in Biomedical Sciences Introduction Type 1 Diabetes is an autoimmune condition ...
    ... homeostasis. Optimal management of Type 1 Diabetes is achieved through insulin pumps and continuous glucose ...
    ... financially burdensome for individuals in a lower socioeconomic status who are dealing with Type 1 Diabetes ...
    ... in a 10-year span. Table 1. This cost analysis shows the cost of insulin injections, -islet cell ...
    Creador:
    Asghar, Shehr
    Descripción:
    Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...
    Tipo de recurso:
    Poster

  • HCAHPS scores as a surrogate for quality does not correlate with TQIP quality measures at a level 1 trauma center

    Creador:
    Thoma-Perry, Carley OMS-4, Jacobsen, L., Blocher-Smith, Ethan C. OMS-4, and Saxe, J.
    Descripción:
    BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
    Tipo de recurso:
    Article

  • Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption

    Coincidencias de palabras clave:
    ... Nutrient sensing by Tas1R proteins is required for normal bone resorption Nicholas 1 Weinstein ...
    ... , Michael 1 Eaton , Stephen 1 Shively , Hannah 2 Davis , Lilian 2 Plotkin , Jonathan W. Lowery 1 1Division ...
    ... 25 3 TAS1R3 2 CTSK 20 F o ld C h a n g e 15 10 1 -actin 5 0 L o K N A RANKL R A R C N o K n L tr + l ...
    ... -Actin 14.83.523 12.882.921 0.6956 8 3 2 1 - + 6 4 2 0 0 1 0 m D 0 C 1 B m M M S S a C cc o h n a tr ri o ...
    ... n l Saccharin p S 6 K in a s e : - A c tin 10 4 0.9639 pS6Kinase 20.783.288 p E R K 1 /2 : - A c ...
    Creador:
    Shively, Stephen, Davis, Hannah M, Weinstein, Nicholas, Eaton, Michael, Plotkin, Lillian, and Lowery, Jonathan
    Descripción:
    Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
    Tipo de recurso:
    poster

  • The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

    Coincidencias de palabras clave:
    ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...
    ... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...
    ... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...
    ... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...
    ... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...
    Creador:
    Zhou, G., Doci, Colleen L., and Lingen, M.W.
    Descripción:
    Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
    Tipo de recurso:
    Article

  • Single-Center Denial Reasons for Potential Living Kidney Donors

    Coincidencias de palabras clave:
    ... 41 40 36 35 30 20 27 24 25 5 0 2012-2015 17 15 10 2009-2011 6 9 11 10 10 6 2 3 2 2 0 1 MEDICAL ...
    ... candidates between 8/2012 and 6 /2015. During the interval, our acceptance ...
    ... abuse. Table 1. Outcome of kidney donor evaluation by year Approved Withdrew Recipient ...
    ... Psychosocial Decision pending 8/12-1 2/12 n = 88 54 (61%) 7 (8%) 4 (5%) 0 0 23 (26%) 17 (74%) 6 ...
    ... (26%) 0 Table 2. Medical reasons for donor denial by age, 8/2012-6/2015. Age 18-2 9 ...
    Creador:
    Lien, Savahanna, Matas, Arthur, Voges, Margaret, and Garvey, Cathy
    Descripción:
    Because of the benefits of preemptive living donor (LD) transplant, the desire for LD is rising. However, in the last decade, there has been no increase in LD in the U.S, possibility due to older donor candidate population...
    Tipo de recurso:
    poster

  • Loss of BMPR2 Expression in Skeletal Progenitor Cells Reduces Age-Related Bone Loss

    Coincidencias de palabras clave:
    ... . Aaron M. 1 Hudnall , Jordan B. 1, 2 Newby , Vicki 3 Rosen , Jonathan W. 1 Lowery = -39.4 mgHA/ccm CI ...
    ... . = -71.11 mgHA/ccm CI: -67.4,-74.8 vBMD (mgHA/ccm) vBMD (mgHA/ccm) Conclusions: vBMD (mgHA/ccm) Fig. 1 ...
    ... Bmpr2fl/fl; Prx1-Cre+ males with Bmpr2fl/fl females (Lowery et al., Journal of Cell Science 2015). At ...
    ... -week-old humerii (Lowery et al., Journal of Cell Science 2015). B, C: As previously reported (Lowery et ...
    ... al., Journal of Cell Science 2015), osteoblast density (B) using standard analysis of number of ...
    Creador:
    Rosen, Vickie, Hudnall, Aaron, Eaton, Michael, Newby, Jordan, and Lowery, Jonathan
    Descripción:
    Osteoporosis is a disease of low bone mineral density (BMD) that affects 10 million Americans with an additional 34 million at risk for developing the disease. Current FDA-approved therapies for osteoporosis involve...
    Tipo de recurso:
    poster