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  • Role of CaMKK2 in Mechanical Stimulation of Bone

    Creador:
    Patel, Sheel, Bello, Margaret , Warrick, Adam , Sankar, Uma, Robling, Alexander , Thompson, William, Shutter, Jennifer , Bellido, Teresita , and Williams, Justin
    Descripción:
    There is a need for anabolic therapies to treat degenerative bone diseases. Mechanical loading stimulates anabolic and inhibits catabolic pathways of bone leading to increased bone formation. Osteocytes are the bone cell...
    Tipo de recurso:
    Poster

  • Mechanical stimulation in vitro regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies for osteopenia and sarcopenia

    Creador:
    Larsen, Bryan, Ogunbekun, Oladipupo, Loghmani, M. Terry, Thompson, William, Hum, Julia, Hiland, Taylor, Lowery, Jonathan, Mahoney, Aaron, and Anloague, Aric
    Descripción:
    Objecti ve: Soft tissue manual therapies are commonly utilized by osteopathic physicians, chiropractors, physical therapists and massage therapists. These techniques are predicated on subjecting tissues to biophysical...
    Tipo de recurso:
    Poster

  • Bone-derived Sclerostin has endocrine actions in adipocyte precursors and pancreatic beta-cells

    Creador:
    Nelson, Jessica, Ghazzawi, Ziad, Evans-Molina, Carmela, Thompson, William, Cregor, Meloney, Bellido, Teresita, Daniel, Ashley, Delgado-Calle, Jesus, Ferrari, Adam, Sabol, Hayley, and McAndrews, Kevin
    Descripción:
    Osteocyte (Ot)-derived Sclerostin (Scl) has local actions in bone mediated by Lrp 4/5/6 receptors, inhibiting bone formation and stimulating bone resorption by antagonizing Wnt signaling. Emerging evidence suggests that Scl...
    Tipo de recurso:
    poster

  • Osteocyte-Specific Deletion of the α2δ1 Auxiliary Voltage Sensitive Calcium Channel Subunit

    Creador:
    Yi, Xin, Schneider, Artur, Wright, Christian, Hum, Julia, and Thompson, William
    Descripción:
    Context: Skeletal unloading due to disuse, disease, or aging increases bone loss and the risk of skeletal fracture. Conversely, mechanical loading is anabolic to the skeleton, promoting skeletal integrity through increased bone...
    Tipo de recurso:
    poster