Student Publications and Research - MUCOM

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41. Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health

Title Tesim:
Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health
Creator:
Larsen, Bryan, Wittman, Emma OMS-2, and Yar, Neela
Related Url Tesim:
https://www.scirp.org/journal/paperinformation.aspx?paperid=101985
Description:
Posted on Open Journal of Obstetrics and Gynecology, https://www.scirp.org/journal/paperinformation.aspx?paperid=101985 and This paper explores one of the underappreciated reasons for lack of efficacy in certain cases of antimicrobial therapy, namely the occurrence of a non-genetic resistance to antimicrobial drugs due to a metabolic quiescence of microorganisms. This review has centered on those microorganisms of particular importance in obstetrics and gynecology and accordingly has reviewed the nature and extent of the persister phenotype in relation to infectious agents affecting women’s health. We show how the quiescent persister microbial phenotype represents the next significant issue that could compromise successful antibiotic therapy. A brief history of antimicrobial therapy is provided as context for the problem posed by the persister phenotype. This review has been focused on the current literature having relevance for physicians concerned with women’s health. The study of this phenotype has led to increasing understanding of the molecular mechanisms for this state which also provides ideas for rational development of drug candidates to interdict these organisms in human disease and explores the possibility of developing specifically targeted molecules to address persisters, research on screening botanicals, existing drugs and chemicals to discover novel approaches to the clinical consequence of microbial persisters. Of interest in this review, is the return to naturally occurring botanical substances, first to be used as anti-infectives, now being considered as possible agents to address persister microorganisms. Overall this paper aims to provide information tailored especially to the obstetrics and gynecology specialists.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Identifier:
10.4236/ojog.2020.1080096
Type:
Article
Keyword:
Women's Health and Antimicrobial Therapy
Date Created:
8-2020

42. Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health

Title Tesim:
Navigating the Third Frontier of Antimicrobial Therapy to Support Women’s Health
Creator:
Larsen, Bryan, Yar, Neela, and Whitman, Emma OMS-2
Description:
This paper explores one of the underappreciated reasons for lack of efficacy in certain cases of antimicrobial therapy, namely the occurrence of a non-genetic resistance to antimicrobial drugs due to a metabolic quiescence of microorganisms. This review has centered on those microorganisms of particular importance in obstetrics and gynecology and accordingly has reviewed the nature and extent of the persister phenotype in relation to infectious agents affecting women’s health. We show how the quiescent persister microbial phenotype represents the next significant issue that could compromise successful antibiotic therapy. A brief history of antimicrobial therapy is provided as context for the problem posed by the persister phenotype. This review has been focused on the current literature having relevance for physicians concerned with women’s health. The study of this phenotype has led to increasing understanding of the molecular mechanisms for this state which also provides ideas for rational development of drug candidates to interdict these organisms in human disease and explores the possibility of developing specifically targeted molecules to address persisters, research on screening botanicals, existing drugs and chemicals to discover novel approaches to the clinical consequence of microbial persisters. Of interest in this review, is the return to naturally occurring botanical substances, first to be used as anti-infectives, now being considered as possible agents to address persister microorganisms. Overall this paper aims to provide information tailored especially to the obstetrics and gynecology specialists.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Language:
English
Identifier:
10.4236/ojog.2020.1080096
Type:
Article
Keyword:
Mechanisms, Antimicrobial Resistance, Quiescent Microorganisms, Gynecologic Infection, Antibiotic Therapy, and Obstetric Infection
Date Created:
8/1/2020

43. Novel Methods and Considerations for Addressing Aortic Arch Hypoplasia and Coarctation

Title Tesim:
Novel Methods and Considerations for Addressing Aortic Arch Hypoplasia and Coarctation
Creator:
to be added
Description:
Numerous surgical approaches have been proposed to treat aortic arch hypoplasia (Figures 1&2). These repairs can vary based upon patient age (i.e. neonatal vs larger child), and therefore the mobility of the aorta. Most repairs can be classified into two categories - those that incorporate a patch and those that do not. The decision between repairs remains largely experiential, rather than empirical, due to the limited number of reported outcomes. We report early outcomes from a novel surgical paradigm for arch hypoplasia utilizing a beating-heart, modified aortic arch advancement (with anterior patch, Figure 1B) for all neonates and a beating-heart, sliding arch aortoplasty (all-autologous repair, Figure 2) for all children beyond infancy. Additionally, we present computational fluid dynamic (CFD) modeling data to better understand the hemodynamic consequences associated with a patch utilization during neonatal aortic arch advancement (Figure 3).
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Language:
English
Type:
Poster
Keyword:
Aortic Arch Hypoplasia and Coarctation
Date Created:
1/1/2017

44. Osilodrostat for the treatment of Cushing's disease

Title Tesim:
Osilodrostat for the treatment of Cushing's disease
Creator:
Rasool, Syeda and Skinner, Brian
Contributor:
Hum, Julia
Related Url Tesim:
From the publisher website: https://www.tandfonline.com/doi/abs/10.1080/14656566.2021.1897106?journalCode=ieop20 and Available for request from the library catalog: https://marianunivindianapolis.on.worldcat.org/v2/oclc/8942652670
Description:
Introduction The treatment of Cushing’s disease (CD) has been advanced well with the introduction of treatment options like transsphenoidal surgery, radiosurgery, bilateral adrenalectomy, and various classes of medication; however, many patients still fail to achieve disease remission. Osilodrostat, an orally bioavailable adrenal steroidogenesis inhibitor, was approved in the USA and EU in 2020 for the treatment of CD. Areas covered This review provides an overview of Cushing’s disease and the newly FDA approved 11β-hydroxylase inhibitor, osilodrostat, for CD with a focus on pharmacodynamics, pharmacokinetics, safety and efficacy data, and phase 2 and 3 clinical trials. Expert opinion Osilodrostat has proven clinical efficacy and tolerability in phase 2 and 3 trials with CD patients who had an inadequate or reoccurring response to transsphenoidal surgery (TSS) and conventional first-line treatment. The phase 3 trial (LINC3) had 86% of the treatment group respond with normal urinary free cortisol (UFC) level compared to 29% in the placebo group (p < 0.001). Deemed as well-tolerated in all current pivotal trials, oral osilodrostat provides a noninvasive option for patients who cannot undergo surgery or patients who have reoccurring hypercortisolemia.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Language:
English
Publisher:
Taylor & Francis
Identifier:
https://doi.org/10.1080/14656566.2021.1897106
Type:
Article
Keyword:
osilodrostat, steroidogenesis inhibitor, hypercortisolism, LCI699, Cushing's Disease, and endocrinology
Date Created:
2021

45. Pigmented onychomatricoma: a rare mimic of subungual melanoma

Title Tesim:
Pigmented onychomatricoma: a rare mimic of subungual melanoma
Creator:
Gerami, P., Haugh, A. M., Hanson, E., Verzi, A. E., Bubley, J, Zarkhin, Sonya OMS-4, Brieva, J., Isales, M. C. , Guitart, J., and Bertler, D
Related Url Tesim:
Available on Pubmed at the following URL: https://pubmed.ncbi.nlm.nih.gov/29473193/
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Language:
English
Identifier:
10.1111/ced.13418
Type:
Article
Keyword:
Dermatology and Oncology
Date Created:
7/1/2018

46. Preventing Pandemics and Containing Disease: A Proposed Symptoms-Based Syndromic Surveillance System

Title Tesim:
Preventing Pandemics and Containing Disease: A Proposed Symptoms-Based Syndromic Surveillance System
Creator:
Mulye, Minal, Abraham, Benjamin M., Schmid, Aaron, Khan, Israt, and Akbar, Samina
Related Url Tesim:
Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9526117477, http://dx.doi.org/10.34297/AJBSR.2022.15.002108, and Available from the publisher: https://biomedgrid.com/fulltext/volume15/preventing-pandemics-and-containing-disease-a-proposed-symptoms-based-syndromic-surveillance-system.002108.php
Description:
Background: Due to globalization, spread of a pandemic is inevitable as we have seen with COVID-19. Further, increased ease of travel increases the potential and frequency of pandemics. Hence, it is imperative to find solutions to stop the spread of future pandemics at onset. The proposed solution is a self-reported, symptoms-based syndromic surveillance system that is universal, interactive, integrative, and combined with artificial intelligence. Once developed, this framework has the potential to stop any future epidemics and pandemic in urban and rural areas worldwide. Methods: We conducted a thorough literature review of existing short message service (SMS, text messaging) and interactive voice response (IVR, calling) surveillance systems, identified and addressed the shortcomings. We considered artificial intelligence applicability in this paradigm and cost-versus-benefit analysis in a myriad of economies. Results: Utilizing social psychology studies regarding user compliance, high-quality systematic analyses of SMS/IVR-based reporting tools, artificial intelligence prediction models, and a review of data-sharing laws, we have found that many of the previous syndromic surveillance models suffer from data fragmentation, thus hindering their scalability to a global setting. Conclusions: This proposal will allow decision-making officials and healthcare professionals to robustly identify local disease outbreaks, thus thwarting unchecked spread while preventing a breakdown in the supply chain. Since communicable pathogens can cause high morbidity and mortality as well as a negative impact on economies, we call upon today’s high-tech companies as well as governmental bodies to be the impetus for the change that will decrease the multifaceted burdens on our global society.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
License Tesim:
https://creativecommons.org/licenses/by/4.0/
Language:
English
Publisher:
American Journal of Biomedical Science & Research
Identifier:
DOI: 10.34297/AJBSR.2022.15.002108
Type:
Article
Keyword:
SARS-CoV-2, COVID-19, Pandemic, Epidemic, Syndromic Surveillance, and Prevention
Date Created:
2022

47. PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR

Title Tesim:
PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
Creator:
Edwards, C., Kane, J., Johnson, J., Hernandez Diaz, M., Vecchi, L., Bracey, K., Omokehinde, T., Fontana, J., Karno, B., Scott, H. , Vogel, Carolina, J. , Lowery, Jonathan W., Martin, T., Johnson, R. , Smith, J., and Grant, D.
Related Url Tesim:
Available from the publisher: https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-024-01791-z#additional-information and Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/10162882228
Description:
The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by assessing the role of specific biological domains of PTHrP in tumor progression through stable expression of PTHrP (-36-139aa) or truncated forms with deletion of the nuclear localization sequence (NLS) alone or in combination with the C-terminus. Although the full-length PTHrP molecule (-36-139aa) did not alter tumorigenesis, PTHrP lacking the NLS alone accelerated primary tumor growth by downregulating p27, while PTHrP lacking the NLS and C-terminus repressed tumor growth through p27 induction driven by the tumor suppressor leukemia inhibitory factor receptor (LIFR). Induction of p27 by PTHrP lacking the NLS and C-terminus persisted in bone disseminated cells, but did not prevent metastatic outgrowth, in contrast to the primary tumor site. These data suggest that the PTHrP NLS functions as a tumor suppressor, while the PTHrP C-terminus may act as an oncogenic switch to promote tumor progression through differential regulation of p27 signaling.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
License Tesim:
https://creativecommons.org/licenses/by/4.0/
Language:
English
Publisher:
Springer Nature and BMC
Identifier:
DOI: https://doi.org/10.1186/s13058-024-01791-z
Type:
Article
Keyword:
parathyroid hormone (PTH)-related protein (PTHrP), breast cancer, PTHrP (-36-139aa) , nuclear localization sequence (NLS), tumorigenesis, leukemia inhibitory factor receptor (LIFR), and tumor suppressor
Date Created:
2024

48. Role of a Transient Receptor Potential Channels in Marfan Syndrome-induced Aortopathy and Cardiomyopathy

Title Tesim:
Role of a Transient Receptor Potential Channels in Marfan Syndrome-induced Aortopathy and Cardiomyopathy
Creator:
Westergaard, NM, Qian, L, Turek, JW, and Cavanaugh, Nicholas B.
Description:
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. While significant advances in the understanding of TGF-? signaling have led to promising therapeutic targets for the treatment of aortopathy, clinical studies have tempered this optimism. In particular, these studies suggest additional signaling pathways that play a significant role in aortic disease progression. Furthermore, even less is known with respect to effectors involved in MFS-induced cardiomyopathy. To date, studies aimed at elucidating molecular mechanisms involved in MFS-induced disease progression have been hampered by the lack of an accelerated disease model. Meanwhile, transient receptor potential (TRP) channels have been implicated as key effectors in other vascular smooth muscle and cardiomyocyte pathologies, yet there is a paucity of investigation focused on their involvement in the aortopathy and cardiomyopathy of MFS. In these studies, we investigate the importance of TRP channels in the pathogenesis of MFS-induced aortopathy and cardiomyopathy by evaluating differential expression in a novel murine model of accelerated MFS etiology
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Language:
English
Type:
Presentation
Keyword:
Marfan Syndrome
Date Created:
9/16/2016

49. A Searchable Database of Medical Education Objectives - Creating A Comparable Gold Standard

Title Tesim:
A Searchable Database of Medical Education Objectives - Creating A Comparable Gold Standard
Creator:
Arbor, Sage, Brooks, Sam, and Biala, Namita OMS-3
Related Url Tesim:
Available from Pubmed: https://pubmed.ncbi.nlm.nih.gov/29499684/ and Available from the publisher: https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-018-1136-z
Description:
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common "gold standard" resource used building curricula are medical objectives suggested by national societies. Unfortunately these objectives suffer from several functional limitations such as limited accessibility to society members, non-searchable formats (such as nested tables or pdf images), and inability to compare and search across societal objectives for redundancy or gaps. The shift towards integrated curriculums in medical school also highlights the need to access suggested content across classical discipline categories. MAIN BODY: We have codified recommendations from national societies in the United States for medical school objectives in a common tabular format and developed an open access database which can be searched across disciplines and societies. A front end website that allows for searching objectives by keyword while filtering on society or discipline was created. The objectives returned from the initial search can be subsearched by a second term. There is a large range in the format, age, breadth, quantity, and quality of objectives from different societies. Some unique disciplines have overlapping suggested content though most of the content does seem "binnable" by discipline. The choice of metadata for objectives from each given society was also very inconsistent. CONCLUSION: A free and searchable database of medical content to deliver during medical school has been developed with over 13,000 objectives from 18 societies and 22 disciplines at http://data.medobjectives.marian.edu/ . The normalization of the different disciplines' objectives into a common database allows a platform to standardize objectives moving forward. Future work could include adding user accounts to access the database, submission of new objectives, voting up and down suggested objectives, and adding "answers" mapped to objectives. Keyword tagging could allow import of content (e.g. PowerPoints) and outputting of suggested objectives, which would also allow comparison of curriculum across medical schools.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Publisher:
Biomed Central
Identifier:
10.1186/s12909-018-1136-z
Type:
Article
Keyword:
Medical Education
Date Created:
3-2-2018

50. A searchable database of medical education objectives - creating a comparable gold standard.

Title Tesim:
A searchable database of medical education objectives - creating a comparable gold standard.
Creator:
Arbor, Sage, Biala, Namita OMS-III, and Brooks, Sam
Description:
BACKGROUND: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common "gold standard" resource used building curricula are medical objectives suggested by national societies. Unfortunately these objectives suffer from several functional limitations such as limited accessibility to society members, non-searchable formats (such as nested tables or pdf images), and inability to compare and search across societal objectives for redundancy or gaps. The shift towards integrated curriculums in medical school also highlights the need to access suggested content across classical discipline categories. MAIN BODY: We have codified recommendations from national societies in the United States for medical school objectives in a common tabular format and developed an open access database which can be searched across disciplines and societies. A front end website that allows for searching objectives by keyword while filtering on society or discipline was created. The objectives returned from the initial search can be subsearched by a second term. There is a large range in the format, age, breadth, quantity, and quality of objectives from different societies. Some unique disciplines have overlapping suggested content though most of the content does seem "binnable" by discipline. The choice of metadata for objectives from each given society was also very inconsistent. CONCLUSION: A free and searchable database of medical content to deliver during medical school has been developed with over 13,000 objectives from 18 societies and 22 disciplines at http://data.medobjectives.marian.edu/ . The normalization of the different disciplines' objectives into a common database allows a platform to standardize objectives moving forward. Future work could include adding user accounts to access the database, submission of new objectives, voting up and down suggested objectives, and adding "answers" mapped to objectives. Keyword tagging could allow import of content (e.g. PowerPoints) and outputting of suggested objectives, which would also allow comparison of curriculum across medical schools.
Rights statement:
http://rightsstatements.org/vocab/InC/1.0/
Language:
English
Identifier:
10.1186/s12909-018-1136-z
Type:
Article
Keyword:
medical education objectives
Date Created:
3/2/2018