Student Publications and Research - MUCOM
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51. Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD
- Title Tesim:
- Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD
- Schöpfer:
- Liesen, Michael P., Agoro, R., Swallow, E., Noonan, M., Ni, P., Damrath, J., Wallace, J., Clinkenbeard, E., Allen, M., White, K. , and Hum, Julia
- Related Url Tesim:
- Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9530318928 and Available from the publisher website: https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15307
- Beschreibung:
- Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) pa- tients as a phosphate (Pi) binder for dialysis-dependent CKD, and for iron de- ficiency anemia (IDA) in non-dialysis CKD. Elevated Pi and IDA both lead to increased FGF23, however, the roles of iron and FGF23 during CKD remain un- clear. To this end, iron and Pi metabolism were tested in a mouse model of CKD (0.2% adenine) ± 0.5% FC for 6 weeks, with and without osteocyte deletion of Fgf23 (flox-Fgf23/Dmp1-Cre). Intact FGF23 (iFGF23) increased in all CKD mice but was lower in Cre+ mice with or without FC, thus the Dmp1-Cre effectively reduced FGF23. Cre+ mice fed AD- only had higher serum Pi than Cre− pre- and post- diet, and the Cre+ mice had higher BUN regardless of FC treatment. Total serum iron was higher in all mice receiving FC, and liver Tfrc, Bmp6, and hepci- din mRNAs were increased regardless of genotype; liver IL- 6 showed decreased mRNA in FC- fed mice. The renal 1,25-dihydroxyvitamin D (1,25D) anabolic enzyme Cyp27b1 had higher mRNA and the catabolic Cyp24a1 showed lower mRNA in FC- fed mice. Finally, mice with loss of FGF23 had higher bone corti- cal porosity, whereas Raman spectroscopy showed no changes in matrix mineral parameters. Thus, FC- and FGF23-dependent and - independent actions were identified in CKD; loss of FGF23 was associated with higher serum Pi and BUN, demonstrating that FGF23 was protective of mineral metabolism. In contrast, FC maintained serum iron and corrected inflammation mediators, potentially pro- viding ancillary benefit.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Lizenz:
- https://creativecommons.org/licenses/by/4.0/
- Sprache:
- English
- Herausgeber:
- The Physiological Society
- Identifikator:
- DOI: https://doi.org/10.14814/phy2.15307
- Ressourcentyp:
- Article
- Stichwort:
- iron, ferric citrate, CKD, klotho, GF23, and kidney
- Datum erstellt:
- 2022
52. Short Limbs, Earlier Diagnosis: Antenatal Presentation of Cornelia de Lange Syndrome
- Title Tesim:
- Short Limbs, Earlier Diagnosis: Antenatal Presentation of Cornelia de Lange Syndrome
- Schöpfer:
- Schoenfeld, Ellen E. and Plenty, Nicole
- Beschreibung:
- Case Study: Short Limbs, Earlier Diagnosis: Antenatal Presentation of Cornelia de Lange Syndrome. 30-year old female presented at 35 weeks gestation to Maternal-Fetal Medicine with intrauterine growth restriction (IUGR) • 9 weeks: Demise of two fetuses in the triplet trichorionic gestation • 11 weeks: Growth restriction of the remaining triplet noted. Negative genetic testing does not exclude the diagnosis of CdLS, which should remain in the differential diagnosis with antenatal findings of frontal bossing, micromelia, and first trimester IUGR.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Ressourcentyp:
- Poster
- Stichwort:
- Cornelia de Lange Syndrome
- Datum erstellt:
- 3/20/2018
53. Side Effects With a Focus on Lymphadenopathy Following COVID-19 Vaccination in Pediatric and AYA Oncology Patients
- Title Tesim:
- Side Effects With a Focus on Lymphadenopathy Following COVID-19 Vaccination in Pediatric and AYA Oncology Patients
- Schöpfer:
- Belsky, J., Carroll, Whitney R., Xu, Guang, and Jacob, S.
- Related Url Tesim:
- Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9753631805 and Available from publisher: https://oce.ovid.com/article/00043426-202303000-00007/HTML#contributor-%C2%A7
- Beschreibung:
- The Coronavirus Disease 2019 (COVID-19) pandemic led to the swift development of multiple vaccinations. Vaccine side effects were well-documented in the healthy adult cohort and included fever and lymphadenopathy, however, side effects in the pediatric immunocompromised population have not been reported. This retrospective study investigated vaccine-eligible children and adolescent young adult oncology patients 12 to 35 years old. We found uncommon, mild, and self-limiting side effects among pediatric cancer patients and survivors. This data will help guide pediatric and AYA oncologists in providing anticipatory guidance and serve as a guide to managing lymphadenopathy as a potential confounder of malignancy.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Herausgeber:
- Wolters Kluwer Health, Inc.
- Identifikator:
- Doi: 10.1097/MPH.0000000000002621
- Ressourcentyp:
- Article
- Stichwort:
- pediatric oncology, supportive care, COVID-19, and vaccination
- Datum erstellt:
- 2023
54. Side Effects With a Focus on Lymphadenopathy Following COVID-19 Vaccination in Pediatric and AYA Oncology Patients
- Title Tesim:
- Side Effects With a Focus on Lymphadenopathy Following COVID-19 Vaccination in Pediatric and AYA Oncology Patients
- Schöpfer:
- Belsky, J., Carroll, Whitney R., Xu, Guang, and Jacob, S.
- Related Url Tesim:
- Available from PubMed: https://pubmed.ncbi.nlm.nih.gov/36716067/, Available from PubMed Central: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025933/, Available from publisher: https://journals.lww.com/jpho-online/Fulltext/2023/03000/Side_Effects_With_a_Focus_on_Lymphadenopathy.7.aspx, and Available from library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9753631805
- Beschreibung:
- The Coronavirus Disease 2019 (COVID-19) pandemic led to the swift development of multiple vaccinations. Vaccine side effects were well-documented in the healthy adult cohort and included fever and lymphadenopathy, however, side effects in the pediatric immunocompromised population have not been reported. This retrospective study investigated vaccine-eligible children and adolescent young adult oncology patients 12 to 35 years old. We found uncommon, mild, and self-limiting side effects among pediatric cancer patients and survivors. This data will help guide pediatric and AYA oncologists in providing anticipatory guidance and serve as a guide to managing lymphadenopathy as a potential confounder of malignancy.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Herausgeber:
- Wolters Kluwer Health, Inc.
- Identifikator:
- DOI: 10.1097/MPH.0000000000002621 , PMID: 36716067, and PMCID: PMC10025933
- Ressourcentyp:
- Article
- Stichwort:
- pediatric oncology, supportive care, COVID-19, and vaccination
- Datum erstellt:
- 2023
55. Sliding Arch Aortoplasty with Continuous Coronary Perfusion for Aortic Arch Hypoplasia Beyond Infancy
- Title Tesim:
- Sliding Arch Aortoplasty with Continuous Coronary Perfusion for Aortic Arch Hypoplasia Beyond Infancy
- Schöpfer:
- Holgren, Sarah E., Torres, Jose E., Carlson, Alyse M., Tcheng, Jason W, Cavanaugh, Nicholas B., and Turek, Joseph W
- Related Url Tesim:
- Additional Material found at the following URL: https://www.ctsnet.org/article/beating-heart-sliding-arch-aortoplasty-continuous-coronary-perfusion-aortic-arch-hypoplasia
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Ressourcentyp:
- Poster
- Stichwort:
- Hypoplasia, Sliding Arch Aortoplasty, and Continuous Coronary Perfusion
- Datum erstellt:
- 1/1/2016
56. Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain
- Title Tesim:
- Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain
- Schöpfer:
- Marciano, Carmela L., Hiland, Taylor A., Chu, TM, Kang, Kyung S., Lowery, Jonathan W., Jackson, Krista L., Street, Sierra, Maris, Carson, Ehrsam, Andrew, Hum, Julia M. , and Loghmani, M
- Related Url Tesim:
- Available from the publisher: https://www.mdpi.com/1422-0067/24/18/14392
- Beschreibung:
- Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive interventions. Soft tissue manipulation (STM), such as massage, has been shown to be effective in human subjects, but the molecular mechanisms underlying these findings are not well understood. In this paper, we evaluated potential changes in the soft tissue levels of more than thirty pro- or anti-inflammatory cytokines following instrument-assisted STM (IASTM) in rats with chronic, induced LBP using Complete Freund’s Adjuvant. Our results indicate that IASTM is associated with reduced soft tissue levels of Regulated on Activation, Normal T cell Expressed and Secreted (RANTES)/Chemokine (C-C motif) ligand 5 (CCL5) and increased soft tissue levels of Interleukin (IL)-4, which are pro-inflammatory and anti-inflammatory factors, respectively, by 120 min post-treatment. IASTM was not associated with tissue-level changes in C-X-C Motif Chemokine Ligand (CXCL)-5/Lipopolysaccharide-Induced CXC Chemokine (LIX)–which is the murine homologue of IL-8, CXCL-7, Granulocyte-Macrophage-Colony Simulating Factor (GM-CSF), Intercellular Adhesion Molecule (ICAM)-1, IL1-Receptor Antagonist (IL-1ra), IL-6, Interferon-Inducible Protein (IP)-10/CXCL-10, L-selectin, Tumor Necrosis Factor (TNF)-α, or Vascular Endothelial Growth Factor (VEGF) at either 30 or 120 min post-treatment. Combined, our findings raise the possibility that IASTM may exert tissue-level effects associated with improved clinical outcomes and potentially beneficial changes in pro-/anti-inflammatory cytokines in circulation and at the tissue level. This article belongs to the Special Issue Molecular Mechanisms and Therapeutic Strategies of Inflammatory Pain.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Lizenz:
- https://creativecommons.org/licenses/by/4.0/
- Sprache:
- English
- Herausgeber:
- MDPI
- Identifikator:
- Doi: https://doi.org/10.3390/ijms241814392
- Ressourcentyp:
- Article
- Stichwort:
- inflammation, massage, soft tissue manipulation, cytokine, low back pain, and musculoskeletal
- Datum erstellt:
- 2023
57. Superficial Ulnar Artery with High Bifurcation of the Brachial Artery and its Clinical Significance
- Title Tesim:
- Superficial Ulnar Artery with High Bifurcation of the Brachial Artery and its Clinical Significance
- Schöpfer:
- Sheng, Max OMS-2, Sheikh, Kabir OMS-2, Patel, Lajja OMS-2, Sieger, Jacob OMS-2, Parker, Emily OMS-2, and Sakthi Velavan, Sumathilatha
- Beschreibung:
- Although the variations in brachial artery branching patterns are commonly observed, only 3.75% exhibit a high ulnar artery variation1. An even fewer number present with a bilateral superficial ulnar artery, as was reported by Fadel and Amonoo-Kuofi2. The compounding variations of a high bifurcation of the brachial artery and a superficial ulnar artery may be asymptomatic, but demonstrate important clinical significance in relation to accidental intra-arterial injections, errors in blood pressure readings, as well as orthopedic, plastic and vascular surgeries of the upper limbs1. This study aims to expand upon previous literature and provide additional insight to the field of clinical anatomy, while educating physicians of the possible presentations and potentially severe risks associated with these variations.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Ressourcentyp:
- Poster
- Stichwort:
- Clinical Anatomy, Superficial Ulnar Artery, Brachial Artery, and Bifurcation
- Datum erstellt:
- 7/1/2018
58. Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
- Title Tesim:
- Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
- Schöpfer:
- Goode, Roy A., Hum, Julia M., and Kalwat, M.
- Related Url Tesim:
- Available from the publisher: https://academic.oup.com/endo/article-abstract/164/1/bqac193/6836713 and Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9688508394
- Beschreibung:
- Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-cells themselves. Restoration of regulated insulin production is a predominant goal of translational diabetes research. Here, we provide a brief overview of recent advances in the fields of β-cell proliferation, regeneration, and replacement. The discovery of therapeutic targets and associated small molecules has been enabled by improved understanding of β-cell development and cell cycle regulation, as well as advanced high-throughput screening methodologies. Important findings in β-cell transdifferentiation, neogenesis, and stem cell differentiation have nucleated multiple promising therapeutic strategies. In particular, clinical trials are underway using in vitro–generated β-like cells from human pluripotent stem cells. Significant challenges remain for each of these strategies, but continued support for efforts in these research areas will be critical for the generation of distinct diabetes therapies.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Herausgeber:
- Oxford University Press on behalf of the Endocrine Society
- Identifikator:
- Doi: https://doi.org/10.1210/endocr/bqac193
- Ressourcentyp:
- Article
- Stichwort:
- pancreatic islet beta cells, induced pluripotent stem cells, proliferation, and diabetes
- Datum erstellt:
- 2022
59. Thrombolysis After Protamine Reversal of Heparin for Acute Ischemic Stroke After Cardiac Catheterization: Case Report and Literature Review
- Title Tesim:
- Thrombolysis After Protamine Reversal of Heparin for Acute Ischemic Stroke After Cardiac Catheterization: Case Report and Literature Review
- Schöpfer:
- Panichpisal, K, Schwartz, B G., Warner, D S., Babygirija, R, Biddick, L; , Rovin, R A., Kassam, A B, Sajjad, R., and Chohan, Adil OMS-2
- Related Url Tesim:
- Full Text available at the following address: https://pubmed.ncbi.nlm.nih.gov/30379743/
- Beschreibung:
- BACKGROUND: Patients with an acute ischemic stroke (AIS) following cardiac catheterization (CC) generally do not receive intravenous thrombolysis [intravenous tissue plasminogen activator (IV-tPA)] as it is contraindicated due to the coagulopathy related to the heparin used during the procedure. We report a case of AIS successfully treated with IV thrombolysis following protamine reversal of heparin effect. CASE REPORT: An 87-year-old man with diabetes mellitus, hypertension, neurofibromatosis, and hyperlipidemia underwent elective transradial CC following an abnormal stress test. He had 2 drug-eluting stents for severe stenosis of mid-circumflex and right coronary arteries and received heparin 13,000?IU during procedure. He developed acute left hemiparesis with initial NIH stroke scale (NIHSS) of 4. Computed tomographic scan of the brain and computed tomographic angiogram of head and neck were unremarkable. Bedside activated clotting time was 181. Protamine 40?mg was administered and 30 minutes later, the activated clotting time level was normalized. IV-tPA was administered at 4 hours 25 minutes from his last known well. Within 15 minutes, his NIHSS was 0. Magnetic resonance imaging of brain showed no acute infarction 24 hours after stroke. CONCLUSIONS: There are limited reports of protamine reversal of heparin before IV-tPA administration. To our knowledge, there are only 6 AIS cases including ours. Three cases received 0.6?mg/kg of tPA dose. All have favorable outcomes and no intracranial hemorrhage was reported. Protamine reversal of heparin for AIS after CC seems to be safe. Further studies are needed to confirm the therapeutic safety and efficacy of this strategy.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Identifikator:
- 10.1097/NRL.0000000000000204
- Ressourcentyp:
- Article
- Stichwort:
- Literature Review, Cardiac Catheterization, Thrombolysis, Acute Ischemic Stroke, and Protamine Reversal of Heparin
- Datum erstellt:
- 11/23/2018
60. The Transcriptional Co-Repressor TLE3 Regulates Myogenic Differentiation by Repressing the Activity of the MyoD Transcription Factor
- Title Tesim:
- The Transcriptional Co-Repressor TLE3 Regulates Myogenic Differentiation by Repressing the Activity of the MyoD Transcription Factor
- Schöpfer:
- Addison, William N, Yoda, Tetsuya, Rosen, Vicki, Nakatomi, Mitsushiro, Nakatomi, Chihiro, Urata, Mariko, Hitomi, Suzuro, Osawa, Kenji;, Jimi, Eijiro, Sato, Tsuyoshi, Ono, Yusuke, Kokabu, Shoichiro, Matsubara, Takuma, Hudnall, Aaron M, and Lowery, Jonathan W.
- Related Url Tesim:
- Final version of this article can be found at the following URL: http://www.jbc.org/content/292/31/12885.long Marian University users can access the article here: https://marianunivindianapolis.on.worldcat.org/oclc/7107052084
- Beschreibung:
- Satellite cells are skeletal muscle stem cells that provide myonuclei for postnatal muscle growth, maintenance, and repair/regeneration in adults. Normally, satellite cells are mitotically quiescent, but they are activated in response to muscle injury, in which case they proliferate extensively and exhibit up-regulated expression of the transcription factor MyoD, a master regulator of myogenesis. MyoD forms a heterodimer with E proteins through their basic helix-loop-helix domain, binds to E boxes in the genome and thereby activates transcription at muscle-specific promoters. The central role of MyoD in muscle differentiation has increased interest in finding potential MyoD regulators. Here we identified transducin-like enhancer of split (TLE3), one of the Groucho/TLE family members, as a regulator of MyoD function during myogenesis. TLE3 was expressed in activated and proliferative satellite cells in which increased TLE3 levels suppressed myogenic differentiation, and, conversely, reduced TLE3 levels promoted myogenesis with a concomitant increase in proliferation. We found that, via its glutamine- and serine/proline-rich domains, TLE3 interferes with MyoD function by disrupting the association between the basic helix-loop-helix domain of MyoD and E proteins. Our findings indicate that TLE3 participates in skeletal muscle homeostasis by dampening satellite cell differentiation via repression of MyoD transcriptional activity.
- Erklärung der Rechte:
- http://rightsstatements.org/vocab/InC/1.0/
- Sprache:
- English
- Herausgeber:
- Copyright 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
- Identifikator:
- 10.1074/jbc.M116.774570
- Ressourcentyp:
- Article
- Stichwort:
- Co-Repressor TLE3 , myogenic differentiation, and MyoD transcription
- Datum erstellt:
- 8/4/2017