Faculty Publications and Research - MUCOM
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61. The pandemic silver lining: preparing osteopathic learners to address healthcare needs using telehealth
- Title Tesim:
- The pandemic silver lining: preparing osteopathic learners to address healthcare needs using telehealth
- Creatore:
- Wright, Amanda, Summers, Michael, and Taylor, J.
- Related Url Tesim:
- Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9301470339 and Available from the publisher: https://www.degruyter.com/document/doi/10.1515/jom-2021-0162/html
- Descrizione:
- Context: During the COVID-19 pandemic, many clinicians quickly adapted their way of practicing patient care by offering telehealth and virtual office visits while simultaneously having to minimize direct patient care. The shift in direct clinical learning opportunities provided to third- and fourth-year medical students required a shift in the educational curriculum to develop learner skills around the appropriate use of telehealth in patient care. Objectives: The aim of this project was to provide exposure to students so they could learn the telemedicine equipment and best practices, and how to identify infectious diseases to improve access to care and meet the needs of the patient. Methods In July and August of 2020, the Indiana Area Health Education Centers Program partnered with Marian University College of Osteopathic Medicine (MUCOM) to support a 1 day telehealth simulation (online curriculum, group lecture, and two standardized patient encounters) into their clerkship curriculum. We utilized a retrospective pretest-posttest to assess changes in learner knowledge around telehealth after the program. At the conclusion of the telehealth training program, students were asked to complete a retrospective pretest-posttest assessing their level of preparedness to utilize telehealth equipment, their preparedness to demonstrate “telehealth best practices” in a manner consistent with protecting patient (and data) privacy, their confidence to utilize telehealth for identification of infectious diseases, and their confidence to utilize telehealth to identify proper treatment plans. Results A total of 96 learners completed the program in 2020. Posttest results demonstrate a statistically significant (p<0.05) improvement for learners’ self-reported level of preparedness to utilize telehealth equipment, their preparedness to demonstrate “telehealth best practices” in a manner consistent with protecting patient (and data) privacy, their confidence to utilize telehealth for identification of infectious diseases, and their confidence to utilize telehealth to identify proper treatment plans. Conclusions: Our telehealth curriculum involving a video, interactive learning session, and two standardized patient experiences provided osteopathic medical learners with realistic simulated case scenarios to work through in effort to improve their knowledge and self-efficacy around the utilization of telehealth in practice.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Licenza:
- https://creativecommons.org/licenses/by/4.0/
- Lingua:
- English
- Editore:
- De Gruyter
- Identifier:
- DOI: 10.1515/jom-2021-0162
- Tipo di risorsa:
- Article
- Parola chiave:
- medical education, telehealth, students, self-efficacy, and area health education centers
- data di creazione:
- 2021
62. The patellar ligament: A comprehensive review
- Title Tesim:
- The patellar ligament: A comprehensive review
- Creatore:
- Bennett, K., Vincent, T., and Sakthi Velavan, Sumathilatha
- Related Url Tesim:
- Available for access or request from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/38866730 and Available from the publisher website: https://onlinelibrary.wiley.com/doi/full/10.1002/ca.23791
- Descrizione:
- Abstract The patellar ligament (PL) is an epiphyseal ligament and is part of the extensor complex of the knee. The ligament has gained attention due to its clinical relevance to autograft and tendinopathy. A variety of anatomical variations of the PL such as aplasia, numerical variations, and vascularity are being reported recently by clinicians and anatomists. The aim of this literature was to review the available literature to provide a consensus regarding anatomic variations of the PL, neurovasculature surrounding the PL, histology of the PL, and various aspects of PL measurements with relevance to the surgical considerations and sex and age-related differences. A narrative review of the patellar ligament was performed by conducting a detailed literature search and review of relevant articles. A total of 90 articles on the patellar ligament were included and were categorized into studies based on anatomical variations, neurovasculature, morphometrics, microanatomy, sex and age-related difference, and ACL reconstruction. The anatomical variations and morphometrics of the PL were found to correlate with the frequency of strain injuries, tendinopathy, and efficacy of the PL autograft in anterior cruciate ligament reconstruction. The sex differences in PL measurements and the effect of estrogen on collagen synthesis explained a higher incidence of patellar tendinopathy in women. An awareness of its variations enables careful selection of surgical incisions, thereby avoiding complications related to nerve injury. Accurate knowledge of the PL microanatomy assists in understanding the mechanism of ligament degeneration, rupture, autograft harvesting, and ligamentization results.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Editore:
- American Association of Clinical Anatomists.
- Identifier:
- DOI: 10.1002/ca.23791
- Parola chiave:
- patellar ligament, tendinopathy, anatomic variation, autografts, and elasticity
- data di creazione:
- 2021
63. Periosteal BMP2 Activity Drives Bone Graft Healing.
- Title Tesim:
- Periosteal BMP2 Activity Drives Bone Graft Healing.
- Creatore:
- Cox, K., Gamer, L., Bosshardt, D., Rosen, V., Lowery, Jonathan W., and Chappuis, V.
- Related Url Tesim:
- https://www.clinicalkey.com/service/content/pdf/watermarked/1-s2.0S8756328212009908.pdf?locale=en_US
- Descrizione:
- Bone graft incorporation depends on the orchestrated activation of numerous growth factors and cytokines in both the host and the graft. Prominent in this signaling cascade is BMP2. Although BMP2 is dispensable for bone formation, it is required for the initiation of bone repair; thus understanding the cellular mechanisms underlying bone regeneration driven by BMP2 is essential for improving bone graft therapies. In the present study, we assessed the role of Bmp2 in bone graft incorporation using mice in which Bmp2 has been removed from the limb prior to skeletal formation (Bmp2(cKO)). When autograft transplantations were performed in Bmp2cKO mice, callus formation and bone healing were absent. Transplantation of either a vital wild type (WT) bone graft into a Bmp2(cKO) host or a vital Bmp2(cKO) graft into a WT host also resulted in the inhibition of bone graft incorporation. Histological analyses of these transplants show that in the absence of BMP2, periosteal progenitors remain quiescent and healing is not initiated. When we analyzed the expression of Sox9, a marker of chondrogenesis, on the graft surface, we found it significantly reduced when BMP2 was absent in either the graft itself or the host, suggesting that local BMP2 levels drive periosteal cell condensation and subsequent callus cell differentiation. The lack of integrated healing in the absence of BMP2 was not due to the inability of periosteal cells to respond to BMP2. Healing was achieved when grafts were pre-soaked in rhBMP2 protein, indicating that periosteal progenitors remain responsive in the absence of BMP2. In contrast to the requirement for BMP2 in periosteal progenitor activation in vital bone grafts, we found that bone matrix-derived BMP2 does not significantly enhance bone graft incorporation. Taken together, our data show that BMP2 signaling is not essential for the maintenance of periosteal progenitors, but is required for the activation of these progenitors and their subsequent differentiation along the osteo-chondrogenic pathway. These results indicate that BMP2 will be among the signaling molecules whose presence will determine success or failure of new bone graft strategies.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Lingua:
- English
- Identifier:
- 10.1016/j.bone.2012.07.017
- Tipo di risorsa:
- Article
- Parola chiave:
- Bone Transplantation, Inbred C57BL, Wound Healing, Bone Morphogenetic Protein 2, Cell Differentiation, and Immunohistochemistry
- data di creazione:
- 10/1/2012
64. Physician Resilience and the Little Way
- Title Tesim:
- Physician Resilience and the Little Way
- Creatore:
- Jones, Jeremy
- Related Url Tesim:
- Available from the publisher: https://journals.sagepub.com/doi/10.1177/00243639231200621, Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/10005771593, and Available from The Pulse of Catholic Medicine: https://www.cathmed.org/the-pulse/physician-resilience-and-the-little-way/
- Descrizione:
- Many triggers for shame that lead to physician burnout occur during patient care or the medical learning environment. Many resilience programs are available to medical students and physicians, yet incorporate non-faith principles. The Little Way as developed by St. Thérèse of the Child Jesus would be a most effective way to incorporate spirituality into our daily duties. This article will explain the need for physician resilience and virtue ethics within our profession. Then, the article will describe the Little Way and apply its principles to healthcare to implement a faith-based approach to physician resilience.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Lingua:
- English
- Editore:
- Catholic Medical Association and Sage Publications
- Identifier:
- DOI: https://doi.org/10.1177/00243639231200621
- Tipo di risorsa:
- Article
- Parola chiave:
- physician burnout, resilience programs, virtue ethics, and St. Thérèse of the Child Jesus
- data di creazione:
- 2023
65. Power of Touch
- Title Tesim:
- Power of Touch
- Creatore:
- Geshel, Richard J.
- Related Url Tesim:
- Available from the publisher: https://ebookcentral.proquest.com/lib/marianuin-ebooks/detail.action?docID=7049132 and Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/1337946697
- Descrizione:
- The Power of Touch is written to enlighten on the anatomy and physiology of touch within the brain and how such integration influences our interpretation of objects under tactile stimulation. Touch conveys great power to those attentive to its cues and can serve as a means of influencing others. Touch is the only physical sense that is of itself a love language in need of livening, quickening, and from time to time, revitalizing. Touch is not only powerful for us, but it is also necessary for our development both physically and, more importantly, emotionally. Without touch in the formative years, we may literally fail to thrive. Our digitized world has expanded our horizons of gadgets to engross our time, but the detrimental effects upon relationships and skills touch are expanded upon. Communication involving our tactile sense, as well as looking at touch from a metaphorical perspective, is addressed to view how touch imparts on others. Last, the origins of Osteopathy and how touch in and of itself is pain relieving round out that which are touched upon within.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Lingua:
- English
- Editore:
- Page Publishing, Inc.
- Identifier:
- ISBN: 9781662401091 and ISBN: 9781662401084
- Tipo di risorsa:
- Book
- Parola chiave:
- physical senses, tactile stimulation, and Osteopathy
- data di creazione:
- 2022
66. Prediction of Academic Success in a Biomedical Sciences Program Via a General Knowledge Anatomy Quiz
- Title Tesim:
- Prediction of Academic Success in a Biomedical Sciences Program Via a General Knowledge Anatomy Quiz
- Creatore:
- Godfry, L.H. and Ausel, Erica
- Related Url Tesim:
- Available from the publisher: https://link.springer.com/article/10.1007/s40670-024-02008-w#article-info and Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/10170782449
- Descrizione:
- This communication outlines the use of a General Knowledge Quiz (GKQ) in predicting academic success in higher education. Students’ scores from the GKQ, completed at the start of the academic year, and fall semester exam averages were found to correlated significantly (p = 0.008), demonstrating a link between quiz score and learning outcomes. Moreover, students who averaged below 80% on exams had significantly lower GKQ scores compared to those who achieved passing grades (80–89.9%, p = 0.013; ≥ 89.9%, p = 0.003). This tool can be tailored for early prediction of students who may need additional academic support. Supplementary data file available.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Lingua:
- English
- Editore:
- Springer Nature
- Identifier:
- DOI: https://doi.org/10.1007/s40670-024-02008-w
- Tipo di risorsa:
- Article
- Parola chiave:
- General Knowledge Quiz (GKQ), predicting academic success, and higher education
- data di creazione:
- 2024-03-05
67. Preventing Pandemics and Containing Disease: A Proposed Symptoms-Based Syndromic Surveillance System
- Title Tesim:
- Preventing Pandemics and Containing Disease: A Proposed Symptoms-Based Syndromic Surveillance System
- Creatore:
- Mulye, Minal, Abraham, Benjamin M., Schmid, Aaron, Khan, Israt, and Akbar, Samina
- Related Url Tesim:
- Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9526117477, http://dx.doi.org/10.34297/AJBSR.2022.15.002108, and Available from the publisher: https://biomedgrid.com/fulltext/volume15/preventing-pandemics-and-containing-disease-a-proposed-symptoms-based-syndromic-surveillance-system.002108.php
- Descrizione:
- Background: Due to globalization, spread of a pandemic is inevitable as we have seen with COVID-19. Further, increased ease of travel increases the potential and frequency of pandemics. Hence, it is imperative to find solutions to stop the spread of future pandemics at onset. The proposed solution is a self-reported, symptoms-based syndromic surveillance system that is universal, interactive, integrative, and combined with artificial intelligence. Once developed, this framework has the potential to stop any future epidemics and pandemic in urban and rural areas worldwide. Methods: We conducted a thorough literature review of existing short message service (SMS, text messaging) and interactive voice response (IVR, calling) surveillance systems, identified and addressed the shortcomings. We considered artificial intelligence applicability in this paradigm and cost-versus-benefit analysis in a myriad of economies. Results: Utilizing social psychology studies regarding user compliance, high-quality systematic analyses of SMS/IVR-based reporting tools, artificial intelligence prediction models, and a review of data-sharing laws, we have found that many of the previous syndromic surveillance models suffer from data fragmentation, thus hindering their scalability to a global setting. Conclusions: This proposal will allow decision-making officials and healthcare professionals to robustly identify local disease outbreaks, thus thwarting unchecked spread while preventing a breakdown in the supply chain. Since communicable pathogens can cause high morbidity and mortality as well as a negative impact on economies, we call upon today’s high-tech companies as well as governmental bodies to be the impetus for the change that will decrease the multifaceted burdens on our global society.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Licenza:
- https://creativecommons.org/licenses/by/4.0/
- Lingua:
- English
- Editore:
- American Journal of Biomedical Science & Research
- Identifier:
- DOI: 10.34297/AJBSR.2022.15.002108
- Tipo di risorsa:
- Article
- Parola chiave:
- SARS-CoV-2, COVID-19, Pandemic, Epidemic, Syndromic Surveillance, and Prevention
- data di creazione:
- 2022
68. PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
- Title Tesim:
- PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
- Creatore:
- Edwards, C., Kane, J., Johnson, J., Hernandez Diaz, M., Vecchi, L., Bracey, K., Omokehinde, T., Fontana, J., Karno, B., Scott, H. , Vogel, Carolina, J. , Lowery, Jonathan W., Martin, T., Johnson, R. , Smith, J., and Grant, D.
- Related Url Tesim:
- Available from the publisher: https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-024-01791-z#additional-information and Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/10162882228
- Descrizione:
- The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by assessing the role of specific biological domains of PTHrP in tumor progression through stable expression of PTHrP (-36-139aa) or truncated forms with deletion of the nuclear localization sequence (NLS) alone or in combination with the C-terminus. Although the full-length PTHrP molecule (-36-139aa) did not alter tumorigenesis, PTHrP lacking the NLS alone accelerated primary tumor growth by downregulating p27, while PTHrP lacking the NLS and C-terminus repressed tumor growth through p27 induction driven by the tumor suppressor leukemia inhibitory factor receptor (LIFR). Induction of p27 by PTHrP lacking the NLS and C-terminus persisted in bone disseminated cells, but did not prevent metastatic outgrowth, in contrast to the primary tumor site. These data suggest that the PTHrP NLS functions as a tumor suppressor, while the PTHrP C-terminus may act as an oncogenic switch to promote tumor progression through differential regulation of p27 signaling.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Licenza:
- https://creativecommons.org/licenses/by/4.0/
- Lingua:
- English
- Editore:
- Springer Nature and BMC
- Identifier:
- DOI: https://doi.org/10.1186/s13058-024-01791-z
- Tipo di risorsa:
- Article
- Parola chiave:
- parathyroid hormone (PTH)-related protein (PTHrP), breast cancer, PTHrP (-36-139aa) , nuclear localization sequence (NLS), tumorigenesis, leukemia inhibitory factor receptor (LIFR), and tumor suppressor
- data di creazione:
- 2024
69. Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1
- Title Tesim:
- Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1
- Creatore:
- Subramani, A., Hite, M., Garcia, S., Maxwell, J., Kondee, H., Millican, G., McClelland, Erin E., Seipelt-Thiemann, R., and Nelson, D.
- Related Url Tesim:
- Available from the publisher: https://journals.biologists.com/jcs/article/136/1/jcs260529/286217/Regulation-of-macrophage-IFN-stimulated-gene, Available from PubMed: https://pubmed.ncbi.nlm.nih.gov/36594555/, and Available from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/9728939892
- Descrizione:
- Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and proinflammatory activity. Although this response must be sufficiently vigorous to ensure the successful clearance of pathogens, it must also be carefully regulated to prevent tissue damage. This is controlled in part by CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2), a transcriptional coregulator that limits ISG expression by inhibiting STAT1 and IRF1. Here, we show that the closely related Cited1 is an ISG, which is expressed in a STAT1-dependent manner, and that IFNγ stimulates the nuclear accumulation of CITED1 protein. In contrast to CITED2, ectopic CITED1 enhanced the expression of a subset of ISGs, including Ccl2, Ifit3b, Isg15 and Oas2. This effect was reversed in a Cited1-null cell line produced by CRISPR-based genomic editing. Collectively, these data show that CITED1 maintains proinflammatory gene expression during periods of prolonged IFNγ exposure and suggest that there is an antagonistic relationship between CITED proteins in the regulation of macrophage inflammatory function.
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Licenza:
- https://creativecommons.org/licenses/by/4.0/
- Lingua:
- English
- Editore:
- The Company of Biologists
- Identifier:
- Doi: https://doi.org/10.1242/jcs.260529, PMID: 36594555, and PMCID: PMC10112972
- Tipo di risorsa:
- Article
- Parola chiave:
- Macrophage, Macrophage polarization, Interferon-γ, CITED1, and STAT1
- data di creazione:
- 2023
70. Review Article and Getting to the Heart of the Matter: Myocardial Injury, Coagulopathy, and Other Potential Cardiovascular Implications of COVID-19
- Title Tesim:
- Review Article and Getting to the Heart of the Matter: Myocardial Injury, Coagulopathy, and Other Potential Cardiovascular Implications of COVID-19
- Creatore:
- Akella, K., Pareddy, A., Petrovic, M., Schmid, A., and Sakthi Velavan, Sumathilatha
- Related Url Tesim:
- Available from the publisher website: http://dx.doi.org/10.1155/2021/6693895 and Available for access or request from the library catalog: https://marianunivindianapolis.on.worldcat.org/oclc/962128825
- Descrizione:
- COVID-19 was primarily identified as a respiratory illness, but reports of patients presenting initially with cardiovascular complaints are rapidly emerging. Many patients also develop cardiovascular complications during and after COVID-19 infection. Underlying cardiovascular disease increases the severity of COVID-19 infection; however, it is unclear if COVID-19 increases the risk of or causes cardiovascular complications in patients without preexisting cardiovascular disease. The review is aimed at informing the primary care physicians of the potential cardiovascular complications, especially in patients without underlying cardiovascular disease. A comprehensive literature review was performed on cardiac and vascular complications of COVID-19. The primary cardiac and vascular complications include myocarditis, acute coronary syndrome, myocardial injury, arrhythmia, heart failure, shock, multisystem inflammatory syndrome, venous and arterial thrombotic events, stroke, and coagulopathy. A detailed analysis of the pathogenesis revealed six possible mechanisms: direct cardiac damage, hypoxia-induced injury, inflammation, a dysfunctional endothelial response, coagulopathy, and the catecholamine stress response. Autopsy reports from studies show cardiomegaly, hypertrophy, ventricular dilation, infarction, and fibrosis. A wide range of cardiac and vascular complications should be considered when treating patients with confirmed or suspected COVID-19 infection. Elevated troponin and natriuretic peptides indicate an early cardiac involvement in COVID-19. Continuous monitoring of coagulation by measuring serum D-dimer can potentially prevent vascular complications. A long-term screening protocol to follow-up the patients in the primary care settings is needed to follow-up with the patients who recovered from COVID cardiovascular complications.
- Soggetto:
- COVID-19, Coagulopathy, and Myocardial Injury
- Dichiarazione dei diritti:
- http://rightsstatements.org/vocab/InC/1.0/
- Licenza:
- https://creativecommons.org/licenses/by/4.0/
- Identifier:
- http://dx.doi.org/10.1155/2021/6693895
- Tipo di risorsa:
- Article
- Parola chiave:
- Review, COVID-19, Coagulopathy, and Myocardial Injury
- data di creazione:
- 6 May 2021