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新搜索 Identifier Tesim 10.1152/ajplung.00034.2007

  • Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

    创造者:
    Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.
    描述:
    Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...
    类型:
    Article

  • Clinical Relevance and Mechanisms of Antagonism Between the BMP and Activin/TGF-? Signaling Pathways.

    关键字匹配:
    ... Lung Cell Mol Physiol. 2012;302(6):L604-L615. doi:10.1152/ajplung.00309.2011. The Journal of the ...
    ... . J Appl Physiol (1985). 2010;109(3):635-642. doi:10.1152/japplphysiol.00866.2009. 34. Lee SJ, Reed LA ...
    ... Appl Physiol (1985). 2009;106(4):1356-1364. doi:10.1152/japplphysiol.90719.2008. 38. Bazan IS, Fares WH ...
    ... :10.1152/ajprenal.00071.2011. 51. Yamamoto M, Beppu H, Takaoka K, et al. Antagonism between Smad1 and Smad2 ...
    创造者:
    Arthur JW, Hudnall, AM, and Lowery, Jonathan W.
    描述:
    The transforming growth factor ? (TGF-?) superfamily is a large group of signaling molecules that participate in embryogenesis, organogenesis, and tissue homeostasis. These molecules are present in all animal genomes....
    类型:
    Article

  • Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

    关键字匹配:
    ... Cell Mol Physiol 287: L1241-L1247. doi:10.1152/ajplung. 00239.2004. PubMed: 15286002. 13. Burton VJ ...
    ... hypertension in heterozygous BMPR2-mutant mice. Am J Physiol Heart Circ Physiol 295: H677-H690. doi:10.1152 ...
    ... hypertension. Am J Physiol Regul Integr Comp Physiol 298: R833R842. doi:10.1152/ajpregu.00534.2009. PubMed ...
    ... Physiol 299: R1463-R1477. doi:10.1152/ajpregu.00866.2009. PubMed: 20881097. 32. West J, Cogan J, Geraci M ...
    创造者:
    Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
    描述:
    More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
    类型:
    Article

  • COVID-19 and the PAH patient: A retrospective chart review

    关键字匹配:
    ... Physiology. Lung Cellular and Molecular Physiology, 319(2), L277L288. https://doi.org/10.1152/ajplung ...
    创造者:
    Schmit, Ann
    描述:
    The COVID-19 pandemic has highlighted the need for additional health precautions in medically fragile populations. COVID-19 is a respiratory virus demonstrating increased mortality in individuals with risk factors such as...
    类型:
    Research Paper

  • Dysfunctional Stem and Progenitor Cells Impair Fracture Healing with Age

    关键字匹配:
    ... Heart Circ Physiol 2004; 287: H2651-H2658 [PMID: 15284068 DOI: 10.1152/ajpheart.00332.2004] Yoder MC ...
    ... 344 rats. Am J Physiol Heart Circ Physiol 2003; 285: H1015-H1022 [PMID: 12915388 DOI: 10.1152/ajpheart ...
    ... ; 286: H2249-H2256 [PMID: 14751861 DOI: 10.1152/ajpheart.00854.2003] Ungvari Z, Tarantini S, Kiss T ...
    ... mice. Am J Physiol Heart Circ Physiol 2014; 307: H1754-H1763 [PMID: 25326534 DOI: 10.1152/ajpheart ...
    ... DOI: 10.1152/japplphysiol.01183.2006] Scheubel RJ, Zorn H, Silber RE, Kuss O, Morawietz H, Holtz J ...
    创造者:
    Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.
    描述:
    Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
    类型:
    Article

  • The BMP Pathway and Its Inhibitors in the Skeleton

    创造者:
    Lowery, Jonathan W. and Rosen, V.
    描述:
    Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-? family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and...
    类型:
    Article

  • Bmp2 and Bmp4 Exert Opposing Effects in Hypoxic Pulmonary Hypertension

    创造者:
    Jones, M.T., Frank, D.B., Mortlock, D.P., de Caestecker, M., Chandler, R.L., Anderson, L.A., and Lowery, Jonathan W.
    描述:
    The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is...
    类型:
    Article

  • ID Family Protein Expression and Regulation in Hypoxic Pulmonary Hypertension

    创造者:
    Jones, M.T., Frump, A.L., diCarlo, G.E., Lowery, Jonathan W, Anderson, L.A., and de Caestecker, M.
    描述:
    Bone morphogenetic protein (BMP) signaling has been linked to the development of pulmonary hypertension (PH). Inhibitors of differentiation (ID) proteins (ID1-4) are a family of basic helix-loop-helix transcription factors that...
    类型:
    Article

  • Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD

    关键字匹配:
    ... ://doi.org/10.1152/physrev.00002.2011 Maruyama, N., Otsuki, T., Yoshida, Y., Nagura, C., Kitai, M., Shibahara ...
    创造者:
    Liesen, Michael P., Agoro, R., Swallow, E., Noonan, M., Ni, P., Damrath, J., Wallace, J., Clinkenbeard, E., Allen, M., White, K. , and Hum, Julia
    描述:
    Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) pa- tients as a phosphate (Pi) binder for dialysis-dependent CKD, and for iron de- ficiency anemia (IDA) in non-dialysis CKD. Elevated Pi and IDA...
    类型:
    Article

  • Skeletal muscle mitochondrial dysfunction and muscle and whole body functional deficits in cancer patients with weight loss

    创造者:
    Kaufman, K., Hart, C., Kumar, R., Jatoi, A., Gries, Kevin J., Port, J., Kunz, H., and Lanza, I.
    描述:
    Reductions in skeletal muscle mass and function are often reported in patients with cancer-associated weight loss and are associated with reduced quality of life, impaired treatment tolerance, and increased mortality. Although...
    类型:
    Article