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Nova pesquisa Identifier Tesim R15AG052933 (JC)

  • Effects of FUdR on gene expression in the C. elegans bacterial diet OP50

    Correspondências de palavras-chave:
    ... Number R15AG052933 (JC) and R15AG063103 (RL). The content is solely the responsibility of the authors and ...
    ... out experimental analysis and helped draft the manuscript. JC conceived the study and participated in ...
    ... its design. JC, JW, HTW, and RL participated in the design and investigation of the study. RL and JC ...
    ... acquisition for this research. JC also participated in the formal analysis and coordinated and drafted the ...
    ... elegans. Aging (Albany NY). 2013;5(10):75969. 15. Anderson EN, Corkins ME, Li JC, Singh K, Parsons S ...
    O Criador:
    McIntyre, Grace, Wong, Hoi Tong, Chan, Jason, Wright, Justin, and Lamendella, Regina
    Descrição:
    Objective Many C. elegans aging studies use the compound 5-fluro-2ʹ-deoxyuridine (FUdR) to produce a synchronous population of worms. However, the effects of FUdR on the bacterial gene expression of OP50 E. coli, the primary...
    Tipo:
    Article

  • The functional loss of ceramide metabolism enzymes ceramide synthase and acid sphingomyelinase on lipid metabolism and healthspan

    O Criador:
    Wang, Lou, Staab, Trisha, Radeny, J, McIntyre, Grace, and Chan, Jason
    Descrição:
    The increase in our aging population in combination with the growing incidence of late-life conditions presents a need for research on healthy aging. Here, we present work examining the roles of sphingolipid metabolism on...
    Tipo:
    Conference Proceeding

  • The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging

    Correspondências de palavras-chave:
    ... SelexION for differential mobility spectrometry www.aging-us.com JC conceived all experiments, collected ...
    ... was supported by the National Institutes of Aging (R15AG052933-03). Lipidomic analysis was further ...
    ... ://doi.org/10.1111/acel.13048 PMID:31560163 10. Jov M, Naud A, Aledo JC, Cabr R, Ayala V, PorteroOtin M ...
    ... , Hengartner MO, Gomez M, Riezman H, Martinou JC. Protection of C. elegans from anoxia by HYL-2 ceramide ...
    ... :19385042 68. Nelson JC, Jiang XC, Tabas I, Tall A, Shea S. Plasma sphingomyelin and subclinical ...
    O Criador:
    Staab, Trisha, McIntyre, Grace, Bromley, S., Raftery, D., Chan, Jason, Wang, L., Radeny, J., Bettcher, L., Guillen, Melissa, Peck, M. , and Kalil, A.
    Descrição:
    Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age...
    Tipo:
    Research Paper

  • Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging

    Correspondências de palavras-chave:
    ... computer cluster, on which many of our analyses were run. This work was funded by NIH grant R15AG052933 ...
    ... R, Bhai J, Billis K, Boddu S, Marugn JC, Cummins C, Davidson C, Dodiya K, Fatima R, Gall A, Giron CG ...
    O Criador:
    Brycky, J, Brislawn, C, Chan, Jason, Heibeck, N, Letson, G, Buonaccorsi, V, Unverdorben, L, Emlet, C, Chen See, J, and Lamendella, R
    Tipo:
    Article