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Nova pesquisa Identifier Tesim 10.1038/s41598-019-48053-z

  • Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

    Correspondências de palavras-chave:
    ... : constantinos.mikelis@ttuhsc.edu) Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 1 ...
    ... /10.1038/s41598-019-48053-z 2 www.nature.com/scientificreports/ www.nature.com/scientificreports Figure 1 ...
    ... ://doi.org/10.1038/s41598-019-48053-z 3 www.nature.com/scientificreports/ www.nature.com/scientificreports ...
    ... the VE-cadherin Scientific Reports | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 4 ...
    ... | (2019) 9:11666 | https://doi.org/10.1038/s41598-019-48053-z 5 www.nature.com/scientificreports ...
    O Criador:
    Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
    Descrição:
    Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
    Tipo:
    Article

  • A chromosome-scale genome sequence of sudangrass (Sorghum sudanense) highlights the genome evolution and regulation of dhurrin biosynthesis

    Correspondências de palavras-chave:
    ... comparison for large-scale genomic experiments. Sci Rep 9:10274. https://doi.org/10.1038/s41598-019-46773-w ...
    ... single-copy orthologs. The results indicated that the Sorghum genus diverged from Z. mays about 21.6 Mya ...
    ... enzyme that catalyzes the first committed step of dhurrin biosynthesis, converting L-tyrosine into (Z)-p ...
    ... L-tyrosine into (Z)-p-hydroxyphenylacetaldehyde oxime (Gleadow et al. 2014; Laursen et al. 2016 ...
    ... . https://doi.org/10.1038/s41467-020-20236-7 11. Choi SC, Chung YS, Lee YG et al (2020) Prediction of ...
    O Criador:
    Bible, Paul, W., Wang, L., Jin, P., Zheng, J., Wang, Y., Zhan, Q., Li, J., Liu, Y., and Tu, W.
    Descrição:
    Sudangrass [ Sorghum sudanense (Piper) Stapf] is a hybrid between grain sorghum and its wild relative S. bicolor ssp. verticilliflorum and is grown as a forage crop due to its high biomass production and low dhurrin content...
    Tipo:
    Article

  • Identification of p38 MAPK as a Novel Therapeutic Target for Friedreich’s Ataxia

    Correspondências de palavras-chave:
    ... @mail.med.upenn.edu) SCIENTIFIC Reports | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 1 www.nature.com ...
    ... :10.1038/s41598-018-23168-x 2 www.nature.com/scientificreports/ Figure 2. Partial loss of phenotype in ...
    ... | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 3 www.nature.com/scientificreports/ Figure 3 ...
    ... Reports | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 4 www.nature.com/scientificreports/ Figure 4 ...
    ... fourth bars). SCIENTIFIC Reports | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 5 www.nature.com ...
    O Criador:
    Lin, Daniel, Tobias, John W., Cotticelli, M. Gracia, Ruff, Eric, Wang, Yongping, Xia, Shujuan, Wilson, Robert B., and Kaur, Avinash
    Descrição:
    Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
    Tipo:
    Article

  • Identification of p38 MAPK as a novel therapeutic target for Friedreich's ataxia

    Correspondências de palavras-chave:
    ... @mail.med.upenn.edu) SCIENTIFIC Reports | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 1 www.nature.com ...
    ... :10.1038/s41598-018-23168-x 2 www.nature.com/scientificreports/ Figure 2. Partial loss of phenotype in ...
    ... | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 3 www.nature.com/scientificreports/ Figure 3 ...
    ... Reports | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 4 www.nature.com/scientificreports/ Figure 4 ...
    ... fourth bars). SCIENTIFIC Reports | (2018) 8:5007 | DOI:10.1038/s41598-018-23168-x 5 www.nature.com ...
    O Criador:
    Kaur, Avinash , Wilson, Robert B., Wang, Yongping , Xia, Shujuan , Ruff, Eric , Cotticelli, M Grazia , Tobias, John W. , and Lin, Daniel
    Descrição:
    Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
    Tipo:
    Article

  • Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging

    Correspondências de palavras-chave:
    ... Caenorhabditis elegans. Sci Rep 9:5545. https://doi.org/10.1038/s41598-019-41452-2. 48. Pradel E, Zhang Y, Pujol ...
    ... . elegans. Sci Rep 7:7137. https://doi.org/10.1038/ s41598-017-07222-8. 16. Breton J, Tennoune N, Lucas N ...
    ... ://doi.org/10.1186/s13073-019-0621-2. 12. Ramos-Molina B, Snchez-Alcoholado L, Cabrera-Mulero A ...
    ... . https://doi.org/10.1038/ncb1975. 15. Smolentseva O, Gusarov I, Gautier L, Shamovsky I, DeFrancesco AS ...
    ... / 10.1038/srep04548. Peck BCE, Shanahan MT, Singh AP, Sethupathy P. 2017. Gut microbial inuences on the ...
    O Criador:
    Brycky, J, Brislawn, C, Chan, Jason, Heibeck, N, Letson, G, Buonaccorsi, V, Unverdorben, L, Emlet, C, Chen See, J, and Lamendella, R
    Tipo:
    Article

  • Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD

    Correspondências de palavras-chave:
    ... , 7294. https://doi.org/10.1038/ s41598-018-25439-z Nickolas, T. L., Stein, E. M., Dworakowski, E ...
    ... /10.1038/s41598-019-45335-4 SUPPORTING INFORMATION Additional supporting information may be found in the ...
    ... -Prada, R., Lincoln, J., Hare, J. M., Mundel, P., Morales, A., Scialla, J., Fischer, M., Soliman, E. Z ...
    ... 968. https://doi.org/10.1007/s40265-019-01125-w Hu, M. C., Shi, M., Zhang, J., Quiones, H., Griffith ...
    ... / ASN.2009121311 Imel, E. A., Liu, Z., Coffman, M., Acton, D., Mehta, R., & Econs, M. J. (2020). Oral ...
    O Criador:
    Liesen, Michael P., Agoro, R., Swallow, E., Noonan, M., Ni, P., Damrath, J., Wallace, J., Clinkenbeard, E., Allen, M., White, K. , and Hum, Julia
    Descrição:
    Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) pa- tients as a phosphate (Pi) binder for dialysis-dependent CKD, and for iron de- ficiency anemia (IDA) in non-dialysis CKD. Elevated Pi and IDA...
    Tipo:
    Article

  • Molecular Characterization of Bacterial Community Composition in the Rhizosphere of Invasive Plant Species Amur Honeysuckle (Lonicera Maackii) in an Urban Wetland Forest

    Correspondências de palavras-chave:
    ... Plant Growth. Scientific Reports, 9, Article No. 12832. https://doi.org/10.1038/s41598-019-49216-8 [45 ...
    ... . https://doi.org/10.1038/s41396-019-0543-4 [46] Hugenholtz, P., Goebel, B.M. and Pace, N.R. (1998) Impact ...
    ... Rarity and Invasiveness in Communities. Nature, 417, 67-70. https://doi.org/10.1038/417067a [3] Bever ...
    ... , 731-733. https://doi.org/10.1038/nature02322 [9] Shively, J.M., Samuel English, R., Baker, S.H. and ...
    ... Response Capacities. Nature Communications, 7, Article ID: 12485. https://doi.org/10.1038/ncomms12485 [23 ...
    O Criador:
    Ahmad, Azeem and Akbar, Samina
    Descrição:
    The goal of this research was to determine the effects of the growth of invasive plant Amur Honeysuckle (Lonicera maackii) on the rhizosphere bacterial community composition, and diversity in an urban wetland forest ecosystem....
    Tipo:
    Article

  • The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging

    Correspondências de palavras-chave:
    ... . Sci Rep. 2017; 7:5. https://doi.org/10.1038/s41598-017-00037-7 PMID:28127055 12. Almeida I, Magalhes S ...
    ... Spectrometry-based Metabolomics Data. Sci Rep. 2018; 8:663. https://doi.org/10.1038/s41598-017-19120-0 PMID ...
    ... Figure 3. Lipid profiles vary by age and genotype. Heatmaps showing average z-score of log2 concentration ...
    ... 10-days old. For all, the heatmaps show averaged z scores for the six replicates in each group ...
    ... with a false discovery rate (FDR) of 5%. In the heatmaps, z-scores are calculated by adjusting the data ...
    O Criador:
    Staab, Trisha, McIntyre, Grace, Bromley, S., Raftery, D., Chan, Jason, Wang, L., Radeny, J., Bettcher, L., Guillen, Melissa, Peck, M. , and Kalil, A.
    Descrição:
    Lipid metabolism affects cell and physiological functions that mediate animal healthspan and lifespan. Lipidomics approaches in model organisms have allowed us to better understand changes in lipid composition related to age...
    Tipo:
    Research Paper

  • Building an Epigenetic Database: Reproducibility and Orthogonal Targets

    Correspondências de palavras-chave:
    ... 1.46 3 10.1038/s41598-017-04206 1.17 -6 10.1371/journal.pone.01932 1.33 32 10.1371/journal.pone.01932 ...
    ... /journal.pone.01932 1.49 32 10.1016/j.amjmed.2016.12. 2.10 029 10.1038/s41598-017-04206 1.43 -6 10.1016/j.amjmed ...
    ... ] 1.72 10.1038/jid.2011.162 3.89 10.1111/imj.13094 10.1097/MEG.00000000000 1.30 00915 10.1097/MEG ...
    ... yes/no - binary (1/0) Breast Neoplasms number 1 yes/no 1 binary (1/0) 0.07 10.1186/s13167-016-0069-z 1 ...
    O Criador:
    Arbor, Sage, Given, Scott, Zhang, Eric, and Dryden, Ariel
    Descrição:
    Odds ratios are one of the methods in statistics to quantify how strongly the presence or absence of a property correlates with the presence or absence of another property in a given population. In the biomedical sciences they...
    Tipo:
    poster

  • A New Way to Trace SARS-CoV-2 Variants Through Weighted Network Analysis of Frequency Trajectories of Mutations

    Correspondências de palavras-chave:
    ... variant emergence. Sci. Rep. 11:21068. doi: 10.1038/s41598-021-0 0496-z Chakraborty, D., Agrawal, A., and ...
    ... molecular epidemiology. Nat. Med. 27, 15181524. doi: 10.1038/ s41591-021-01472-w Qin, L., Ding, X., Li, Y ...
    ... -CoV-2 lineages to assist genomic epidemiology. Nat. Microbiol. 5, 14031407. doi: 10.1038/s41564 ...
    ... ., Ehtesham, N. Z., Hira, S., and Hasnain, S. E. (2021). SARSCoV-2 variants of concern are emerging in India ...
    ... . Nat. Med. 27, 11311133. doi: 10.1038/s41591-021-01397-4 Tang, X., Ying, R., Yao, X., Li, G., Wu, C ...
    O Criador:
    Wang, Y., Zhang, Q., Liu, Y., Liang, Q., Zheng, F., Hao, Y., Bible, Paul, W., and Huang, Q.
    Descrição:
    Early detection of SARS-CoV-2 variants enables timely tracking of clinically important strains in order to inform the public health response. Current subtype-based variant surveillance depending on prior subtype assignment...
    Tipo:
    Article