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Nova pesquisa Date Created Tesim 1/1/2013

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    O Criador:
    Eaton, Michael and Newby, Jordan
    Descrição:
    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
    Tipo:
    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    O Criador:
    Ward, Taylor
    Descrição:
    The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
    Tipo:
    poster

  • Investigating the HSF1-HSF2 Interaction

    O Criador:
    Jaeger, Alex, Thiele, Dennis, and Wacker, Bryan
    Descrição:
    The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
    Tipo:
    poster

  • Assessing Patient Perspective of Diet and Exercise in Patients Taking Semaglutide: An Educational Intervention

    Correspondências de palavras-chave:
    ... enough to achieve long-term health benefits. Inclusion Criteria: 1) adult 18 years or older without ...
    ... glucagon-like-peptide (GLP-1) to combat the obesity and diabetic epidemic. Project: 21 days in length with ...
    ... two data collection periods. GLP-1 prompts the body to produce more insulin, reducing blood sugar ...
    ... (glucose). GLP-1 in higher amounts interacts with parts of the brain to suppress appetite and signal ...
    ... medical facility in Indianapolis, IN. Days 1-14: Patients were invited to participate in the project via ...
    O Criador:
    Young, Alexis
    Descrição:
    The DNP project aimed to: assess the effectiveness of an educational intervention focused on improving patient knowledge and receptiveness of making necessary diet and exercise changes during their semaglutide treatment...
    Tipo:
    Poster

  • Disparities & Inequalities in Type 1 Diabetes

    Correspondências de palavras-chave:
    ... Disparities & Inequalities in Type 1 Diabetes By: Shehr Asghar Marian University College of ...
    ... Osteopathic Medicine MS in Biomedical Sciences Introduction Type 1 Diabetes is an autoimmune condition ...
    ... homeostasis. Optimal management of Type 1 Diabetes is achieved through insulin pumps and continuous glucose ...
    ... financially burdensome for individuals in a lower socioeconomic status who are dealing with Type 1 Diabetes ...
    ... in a 10-year span. Table 1. This cost analysis shows the cost of insulin injections, -islet cell ...
    O Criador:
    Asghar, Shehr
    Descrição:
    Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...
    Tipo:
    Poster

  • HCAHPS scores as a surrogate for quality does not correlate with TQIP quality measures at a level 1 trauma center

    O Criador:
    Thoma-Perry, Carley OMS-4, Jacobsen, L., Blocher-Smith, Ethan C. OMS-4, and Saxe, J.
    Descrição:
    BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
    Tipo:
    Article

  • Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption

    Correspondências de palavras-chave:
    ... Nutrient sensing by Tas1R proteins is required for normal bone resorption Nicholas 1 Weinstein ...
    ... , Michael 1 Eaton , Stephen 1 Shively , Hannah 2 Davis , Lilian 2 Plotkin , Jonathan W. Lowery 1 1Division ...
    ... 25 3 TAS1R3 2 CTSK 20 F o ld C h a n g e 15 10 1 -actin 5 0 L o K N A RANKL R A R C N o K n L tr + l ...
    ... -Actin 14.83.523 12.882.921 0.6956 8 3 2 1 - + 6 4 2 0 0 1 0 m D 0 C 1 B m M M S S a C cc o h n a tr ri o ...
    ... n l Saccharin p S 6 K in a s e : - A c tin 10 4 0.9639 pS6Kinase 20.783.288 p E R K 1 /2 : - A c ...
    O Criador:
    Shively, Stephen, Davis, Hannah M, Weinstein, Nicholas, Eaton, Michael, Plotkin, Lillian, and Lowery, Jonathan
    Descrição:
    Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
    Tipo:
    poster

  • The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

    Correspondências de palavras-chave:
    ... antitumorigenic cell phenotypes & 2013 Macmillan Publishers Limited Figure 5. NOL7 coimmunoprecipitates TSP-1 mRNA ...
    ... contribute to Oncogene (2013) 4377 4386 NOL7 post-transcriptionally upregulates TSP-1 CL Doci et al 4382 ...
    ... Oncogene (2013) 32, 43774386 & 2013 Macmillan Publishers Limited All rights reserved 0950-9232/13 ...
    ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...
    ... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...
    O Criador:
    Zhou, G., Doci, Colleen L., and Lingen, M.W.
    Descrição:
    Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
    Tipo:
    Article

  • Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

    Correspondências de palavras-chave:
    ... transcriptional regulation of target genes such as PLOS ONE | www.plosone.org 1 November 2013 | Volume 8 | Issue ...
    ... . Austin4, Mark de Caestecker1,5* 1 Department of Cell and Developmental Biology, Vanderbilt University ...
    ... , Hamid R, Austin ED, de Caestecker M (2013) Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant ...
    ... , United States of America Received July 31, 2013; Accepted October 7, 2013; Published November 5, 2013 ...
    ... Copyright: 2013 Frump et al. This is an open-access article distributed under the terms of the Creative ...
    O Criador:
    Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.
    Descrição:
    More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...
    Tipo:
    Article

  • Comparative Genomics Identifies the Mouse BMP3 Promoter and an Upstream Evolutionary Conserved Region (ECR) in Mammals.

    Correspondências de palavras-chave:
    ... are conserved as early as sponges [2]. PLOS ONE | www.plosone.org 1 February 2013 | Volume 8 | Issue 2 ...
    ... (2013) Comparative Genomics Identifies the Mouse Bmp3 Promoter and an Upstream Evolutionary Conserved ...
    ... , University of South Florida, United States of America Received November 6, 2012; Accepted January 26, 2013 ...
    ... ; Published February 22, 2013 Copyright: 2013 Lowery et al. This is an open-access article distributed under ...
    ... , genomic fragments contained the first 63 nt of Bmp3 exon 1 in order to include the annotated Bmp3 ...
    O Criador:
    LaVigne, AW, Kokabu, S, Lowery, Jonathan W., and Rosen, V.
    Descrição:
    The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes,...
    Tipo:
    Article