Recherche

Nouvelle recherche Identifier Tesim 10.1096/fasebj.2020.34.s1.00629

  • Sema3F Suppresses Tumor Initiation Through Alteration of the Immunological Tumor Microenvironment

    Créateur:
    Doci, C. L., Molinolo, A. M., Gutkind,J. S., Callejas-Valera,J. L., and Mikelis, C. M.
    La description:
    SEMA3F is an antilymphangiogenic signaling molecule expressed in the proliferating basal layer of normal epithelium. In orthotopic models of head and neck squamous cell carcinoma, loss of SEMA3F or its receptors results in...
    Type:
    Article

  • The functional loss of ceramide metabolism enzymes ceramide synthase and acid sphingomyelinase on lipid metabolism and healthspan

    Créateur:
    Wang, Lou, Staab, Trisha, Radeny, J, McIntyre, Grace, and Chan, Jason
    La description:
    The increase in our aging population in combination with the growing incidence of late-life conditions presents a need for research on healthy aging. Here, we present work examining the roles of sphingolipid metabolism on...
    Type:
    Conference Proceeding

  • Dysfunctional Stem and Progenitor Cells Impair Fracture Healing with Age

    Correspondances de mots clés:
    ... cycle. FASEB J 1999; 13: 2265-2276 [PMID: 10593874 DOI: 10.1096/fasebj.13.15.2265] Simm M, Pekarskaya O ...
    ... : 10.1096/fj.08-110296] Khan AS, Lynch CD, Sane DC, Willingham MC, Sonntag WE. Growth hormone increases ...
    Créateur:
    Kacena, M.A., Karnik, S., Li, J., Promer, H.J., Clauss, M., Loghmani, M.T., Wagner, D.R., McKinley, T.O., Nielsen, J.J., Low, P.S., Lowery, Jonathan W., Gunderson, Z.J., and Fennimore, A.
    La description:
    Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new...
    Type:
    Article

  • Klotho Expression in Aging and Disease

    Créateur:
    Choe, David, MacLean, A. G., and Delery, Elizabeth
    La description:
    Klotho is a regulatory anti-aging protein that is significantly expressed in the choroid plexus, plays an important role in regulating the immune response in the CNS, and diminishes with age. It is known that a decline of...
    Type:
    Article

  • Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

    Correspondances de mots clés:
    ... development. FASEB J 22, 18291838, https://doi. org/10.1096/fj.07-096438 (2008). 19. Nohata, N. et al ...
    ... angiogenesis. FASEB J 24, 31863195, https://doi.org/10.1096/fj.09-145102 (2010). 23. Claesson-Welsh, L. Signal ...
    ... through receptor protein tyrosine phosphatase beta/zeta. FASEB J 23, 14591469, https://doi.org/10.1096/fj ...
    Créateur:
    Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
    La description:
    Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
    Type:
    Article

  • SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

    Correspondances de mots clés:
    ... , Room 320, Bethesda, MD 20892-4340, USA. E-mail: sg39v@nih.gov doi: 10.1096/fj.14-260083 This article ...
    Créateur:
    Mikelis, Constantinos M., Zárate-Bladés, Carlos Rodrigo, Leelahavanichkul, Kantima, Wang, Zhiyong, Martin, Daniel, Doci, Colleen L., Dorsam, Robert T., Amornphimoltham, Panomwat, Gutkind, J. Silvio, Patel, Vyomesh, Weigert, Roberto, Masedunskas, Andrius, Molinolo, Alfredo A., and Dillenburg-Pilla, Patricia
    La description:
    Multiple human malignancies rely on C-X-C motif chemokine receptor type 4 (CXCR4) and its ligand, SDF-1/CXCL12 (stroma cell-derived factor 1/C-X-C motif chemokine 12), to metastasize. CXCR4 inhibitors promote the mobilization...
    Type:
    Article

  • Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD

    Correspondances de mots clés:
    ... rescues renal anemia. The FASEB Journal, 32, 37523764. https://doi. org/10.1096/fj.201700667R Agoro, R ...
    Créateur:
    Liesen, Michael P., Agoro, R., Swallow, E., Noonan, M., Ni, P., Damrath, J., Wallace, J., Clinkenbeard, E., Allen, M., White, K. , and Hum, Julia
    La description:
    Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) pa- tients as a phosphate (Pi) binder for dialysis-dependent CKD, and for iron de- ficiency anemia (IDA) in non-dialysis CKD. Elevated Pi and IDA...
    Type:
    Article

  • Epidermal Loss of Gag Confers a Migratory and Differentiation Defect in Keratinocytes

    Correspondances de mots clés:
    ... J. 2007; 21 (14):404758. Epub 2007/07/05. https://doi.org/10.1096/fj.06-7476com PMID: 17609252 38 ...
    Créateur:
    Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
    La description:
    G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
    Type:
    Article

  • Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1

    Correspondances de mots clés:
    ... . FASEB J. 34, 12100-12113. doi:10.1096/fj.202000864R Qin, X., Chen, H., Tu, L., Ma, Y., Liu, N., Zhang, H ...
    Créateur:
    Subramani, A., Hite, M., Garcia, S., Maxwell, J., Kondee, H., Millican, G., McClelland, Erin E., Seipelt-Thiemann, R., and Nelson, D.
    La description:
    Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells, resulting in enhanced antimicrobial and...
    Type:
    Article