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New Search Date Created Tesim 1/1/2011

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Creator:
    Eaton, Michael and Newby, Jordan
    Description:
    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
    Type:
    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Creator:
    Ward, Taylor
    Description:
    The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
    Type:
    poster

  • Investigating the HSF1-HSF2 Interaction

    Creator:
    Jaeger, Alex, Thiele, Dennis, and Wacker, Bryan
    Description:
    The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
    Type:
    poster

  • Assessing Patient Perspective of Diet and Exercise in Patients Taking Semaglutide: An Educational Intervention

    Keyword matches:
    ... enough to achieve long-term health benefits. Inclusion Criteria: 1) adult 18 years or older without ...
    ... glucagon-like-peptide (GLP-1) to combat the obesity and diabetic epidemic. Project: 21 days in length with ...
    ... two data collection periods. GLP-1 prompts the body to produce more insulin, reducing blood sugar ...
    ... (glucose). GLP-1 in higher amounts interacts with parts of the brain to suppress appetite and signal ...
    ... medical facility in Indianapolis, IN. Days 1-14: Patients were invited to participate in the project via ...
    Creator:
    Young, Alexis
    Description:
    The DNP project aimed to: assess the effectiveness of an educational intervention focused on improving patient knowledge and receptiveness of making necessary diet and exercise changes during their semaglutide treatment...
    Type:
    Poster

  • Disparities & Inequalities in Type 1 Diabetes

    Keyword matches:
    ... Disparities & Inequalities in Type 1 Diabetes By: Shehr Asghar Marian University College of ...
    ... Osteopathic Medicine MS in Biomedical Sciences Introduction Type 1 Diabetes is an autoimmune condition ...
    ... homeostasis. Optimal management of Type 1 Diabetes is achieved through insulin pumps and continuous glucose ...
    ... financially burdensome for individuals in a lower socioeconomic status who are dealing with Type 1 Diabetes ...
    ... in a 10-year span. Table 1. This cost analysis shows the cost of insulin injections, -islet cell ...
    Creator:
    Asghar, Shehr
    Description:
    Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...
    Type:
    Poster

  • HCAHPS scores as a surrogate for quality does not correlate with TQIP quality measures at a level 1 trauma center

    Creator:
    Thoma-Perry, Carley OMS-4, Jacobsen, L., Blocher-Smith, Ethan C. OMS-4, and Saxe, J.
    Description:
    BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
    Type:
    Article

  • Effects of Different BMPR2 Mutations on Pulmonary Endothelial Cells from Patients with Hereditary Arterial Pulmonary Hypertension

    Creator:
    de Caestecker, M., Frump, A., and Lowery, Jonathan W.
    Type:
    Conference

  • The Role of BMP2 Signaling in the Skeleton.

    Creator:
    Capelo, L.P., Chappuis, V., Kokabu, S, Lowery, Jonathan W., Rosen, V., Pazin, D., and Intini, G.
    Description:
    While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
    Type:
    Article

  • Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption

    Keyword matches:
    ... Nutrient sensing by Tas1R proteins is required for normal bone resorption Nicholas 1 Weinstein ...
    ... , Michael 1 Eaton , Stephen 1 Shively , Hannah 2 Davis , Lilian 2 Plotkin , Jonathan W. Lowery 1 1Division ...
    ... 25 3 TAS1R3 2 CTSK 20 F o ld C h a n g e 15 10 1 -actin 5 0 L o K N A RANKL R A R C N o K n L tr + l ...
    ... -Actin 14.83.523 12.882.921 0.6956 8 3 2 1 - + 6 4 2 0 0 1 0 m D 0 C 1 B m M M S S a C cc o h n a tr ri o ...
    ... n l Saccharin p S 6 K in a s e : - A c tin 10 4 0.9639 pS6Kinase 20.783.288 p E R K 1 /2 : - A c ...
    Creator:
    Shively, Stephen, Davis, Hannah M, Weinstein, Nicholas, Eaton, Michael, Plotkin, Lillian, and Lowery, Jonathan
    Description:
    Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
    Type:
    poster

  • The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

    Keyword matches:
    ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...
    ... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...
    ... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...
    ... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...
    ... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...
    Creator:
    Zhou, G., Doci, Colleen L., and Lingen, M.W.
    Description:
    Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
    Type:
    Article