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  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Schöpfer:
    Eaton, Michael and Newby, Jordan
    Beschreibung:
    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
    Ressourcentyp:
    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Schöpfer:
    Ward, Taylor
    Beschreibung:
    The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
    Ressourcentyp:
    poster

  • Investigating the HSF1-HSF2 Interaction

    Schöpfer:
    Jaeger, Alex, Thiele, Dennis, and Wacker, Bryan
    Beschreibung:
    The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
    Ressourcentyp:
    poster

  • Assessing Patient Perspective of Diet and Exercise in Patients Taking Semaglutide: An Educational Intervention

    Keyword-Übereinstimmungen:
    ... enough to achieve long-term health benefits. Inclusion Criteria: 1) adult 18 years or older without ...
    ... glucagon-like-peptide (GLP-1) to combat the obesity and diabetic epidemic. Project: 21 days in length with ...
    ... two data collection periods. GLP-1 prompts the body to produce more insulin, reducing blood sugar ...
    ... (glucose). GLP-1 in higher amounts interacts with parts of the brain to suppress appetite and signal ...
    ... medical facility in Indianapolis, IN. Days 1-14: Patients were invited to participate in the project via ...
    Schöpfer:
    Young, Alexis
    Beschreibung:
    The DNP project aimed to: assess the effectiveness of an educational intervention focused on improving patient knowledge and receptiveness of making necessary diet and exercise changes during their semaglutide treatment...
    Ressourcentyp:
    Poster

  • Disparities & Inequalities in Type 1 Diabetes

    Keyword-Übereinstimmungen:
    ... Disparities & Inequalities in Type 1 Diabetes By: Shehr Asghar Marian University College of ...
    ... Osteopathic Medicine MS in Biomedical Sciences Introduction Type 1 Diabetes is an autoimmune condition ...
    ... homeostasis. Optimal management of Type 1 Diabetes is achieved through insulin pumps and continuous glucose ...
    ... financially burdensome for individuals in a lower socioeconomic status who are dealing with Type 1 Diabetes ...
    ... in a 10-year span. Table 1. This cost analysis shows the cost of insulin injections, -islet cell ...
    Schöpfer:
    Asghar, Shehr
    Beschreibung:
    Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...
    Ressourcentyp:
    Poster

  • HCAHPS scores as a surrogate for quality does not correlate with TQIP quality measures at a level 1 trauma center

    Schöpfer:
    Thoma-Perry, Carley OMS-4, Jacobsen, L., Blocher-Smith, Ethan C. OMS-4, and Saxe, J.
    Beschreibung:
    BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
    Ressourcentyp:
    Article

  • Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption

    Keyword-Übereinstimmungen:
    ... Nutrient sensing by Tas1R proteins is required for normal bone resorption Nicholas 1 Weinstein ...
    ... , Michael 1 Eaton , Stephen 1 Shively , Hannah 2 Davis , Lilian 2 Plotkin , Jonathan W. Lowery 1 1Division ...
    ... 25 3 TAS1R3 2 CTSK 20 F o ld C h a n g e 15 10 1 -actin 5 0 L o K N A RANKL R A R C N o K n L tr + l ...
    ... -Actin 14.83.523 12.882.921 0.6956 8 3 2 1 - + 6 4 2 0 0 1 0 m D 0 C 1 B m M M S S a C cc o h n a tr ri o ...
    ... n l Saccharin p S 6 K in a s e : - A c tin 10 4 0.9639 pS6Kinase 20.783.288 p E R K 1 /2 : - A c ...
    Schöpfer:
    Shively, Stephen, Davis, Hannah M, Weinstein, Nicholas, Eaton, Michael, Plotkin, Lillian, and Lowery, Jonathan
    Beschreibung:
    Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
    Ressourcentyp:
    poster

  • The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

    Keyword-Übereinstimmungen:
    ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...
    ... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...
    ... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...
    ... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...
    ... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...
    Schöpfer:
    Zhou, G., Doci, Colleen L., and Lingen, M.W.
    Beschreibung:
    Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
    Ressourcentyp:
    Article

  • COVID-19 and the PAH patient: A retrospective chart review

    Keyword-Übereinstimmungen:
    ... significance between the pre-pandemic period of March 1, 2019, through February 29, 2020, and during the COVID ...
    ... -19 pandemic period of March 1, 2020, through February 28, 2021. This study will increase the ...
    ... al., 2020). Pulmonary arterial hypertension, WHO Group 1, (PAH) is a rare, chronic, progressive ...
    ... between March 1, 2019, to February 29, 2020, as a baseline need of medical services and compared it to the ...
    ... March 1, 2020 February 28, 2021, timeframe when the COVID-19 pandemic occurred. Understanding how ...
    Schöpfer:
    Schmit, Ann
    Beschreibung:
    The COVID-19 pandemic has highlighted the need for additional health precautions in medically fragile populations. COVID-19 is a respiratory virus demonstrating increased mortality in individuals with risk factors such as...
    Ressourcentyp:
    Research Paper

  • Analysis of Incident DKA in the Indiana New Onset T1D Patient Population

    Keyword-Übereinstimmungen:
    ... , Indianapolis Indiana ABSTRACT RESULTS BLOCK 1 COVID-19 RESULTS TABLE Diabetic ko1oacidosis (OKA) is a lifo ...
    ... ,threaloning complication of type 1 d iabetes {T10) resulting from ketone body production and metabolic ...
    ... . Patients diagnosed from March 23 June 30, 2020 and O\ler the same period in 2019 were included. OKAwa:s ...
    ... ! incius.On crlleria. Thete was no significant d ifference in rates of OKA (21 in 2019 vs. 25 in 2020; p>0.05 ...
    ... ). OKA was present in nearly half of all new onset pediatric T1 D cases in Indiana in 2019 and 2020 ...
    Schöpfer:
    Sims, E, Evans-Molina, C, Beer, Brianna, and Moors, K
    Beschreibung:
    Diabetic ketoacidosis (DKA) is a life threatening complication of type 1 diabetes (T1D) resulting from ketone body production and metabolic acidosis occurring due to insulin deficiency, We sought to define the occurrence of DKA...
    Ressourcentyp:
    Poster