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  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Schöpfer:
    Ward, Taylor
    Beschreibung:
    The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
    Ressourcentyp:
    poster

  • Loss of the Nutrient Sensor Tas1R3 Leads to Reduced Bone Resorption

    Schöpfer:
    Eaton, Michael and Newby, Jordan
    Beschreibung:
    Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
    Ressourcentyp:
    poster

  • Investigating the HSF1-HSF2 Interaction

    Schöpfer:
    Jaeger, Alex, Thiele, Dennis, and Wacker, Bryan
    Beschreibung:
    The over accumulation of misfolded protein aggregates is a key contributor in neurodegeneration associated with diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Amyotrophic Lateral Sclerosis (ALS). In a...
    Ressourcentyp:
    poster

  • Assessing Patient Perspective of Diet and Exercise in Patients Taking Semaglutide: An Educational Intervention

    Keyword-Übereinstimmungen:
    ... enough to achieve long-term health benefits. Inclusion Criteria: 1) adult 18 years or older without ...
    ... al., 2016; Kaplan et al., 2018; Rubino et al., 2021; Updike, 2021; Wharton et al. 2022). In 2017 ...
    ... glucagon-like-peptide (GLP-1) to combat the obesity and diabetic epidemic. Project: 21 days in length with ...
    ... two data collection periods. GLP-1 prompts the body to produce more insulin, reducing blood sugar ...
    ... (glucose). GLP-1 in higher amounts interacts with parts of the brain to suppress appetite and signal ...
    Schöpfer:
    Young, Alexis
    Beschreibung:
    The DNP project aimed to: assess the effectiveness of an educational intervention focused on improving patient knowledge and receptiveness of making necessary diet and exercise changes during their semaglutide treatment...
    Ressourcentyp:
    Poster

  • Disparities & Inequalities in Type 1 Diabetes

    Keyword-Übereinstimmungen:
    ... Disparities & Inequalities in Type 1 Diabetes By: Shehr Asghar Marian University College of ...
    ... Osteopathic Medicine MS in Biomedical Sciences Introduction Type 1 Diabetes is an autoimmune condition ...
    ... homeostasis. Optimal management of Type 1 Diabetes is achieved through insulin pumps and continuous glucose ...
    ... financially burdensome for individuals in a lower socioeconomic status who are dealing with Type 1 Diabetes ...
    ... in a 10-year span. Table 1. This cost analysis shows the cost of insulin injections, -islet cell ...
    Schöpfer:
    Asghar, Shehr
    Beschreibung:
    Type 1 Diabetes is an autoimmune condition characterized by a deficiency in insulin due to the destruction of pancreatic β-cells. This leads to elevated blood glucose levels. The primary treatment involves daily administration...
    Ressourcentyp:
    Poster

  • HCAHPS scores as a surrogate for quality does not correlate with TQIP quality measures at a level 1 trauma center

    Schöpfer:
    Thoma-Perry, Carley OMS-4, Jacobsen, L., Blocher-Smith, Ethan C. OMS-4, and Saxe, J.
    Beschreibung:
    BACKGROUND: The Trauma Quality Improvement Program was designed by the American College of Surgeons to measure quality benchmarks across American College of Surgeons-certified trauma centers. The Hospital Consumer Assessment...
    Ressourcentyp:
    Article

  • Nutrient Sensing by Tas1R Proteins is Required for Normal Bone Resorption

    Keyword-Übereinstimmungen:
    ... Nutrient sensing by Tas1R proteins is required for normal bone resorption Nicholas 1 Weinstein ...
    ... , Michael 1 Eaton , Stephen 1 Shively , Hannah 2 Davis , Lilian 2 Plotkin , Jonathan W. Lowery 1 1Division ...
    ... 25 3 TAS1R3 2 CTSK 20 F o ld C h a n g e 15 10 1 -actin 5 0 L o K N A RANKL R A R C N o K n L tr + l ...
    ... -Actin 14.83.523 12.882.921 0.6956 8 3 2 1 - + 6 4 2 0 0 1 0 m D 0 C 1 B m M M S S a C cc o h n a tr ri o ...
    ... n l Saccharin p S 6 K in a s e : - A c tin 10 4 0.9639 pS6Kinase 20.783.288 p E R K 1 /2 : - A c ...
    Schöpfer:
    Shively, Stephen, Davis, Hannah M, Weinstein, Nicholas, Eaton, Michael, Plotkin, Lillian, and Lowery, Jonathan
    Beschreibung:
    Current therapies for low bone mass consist of inhibiting osteoclast activity or increasing the PTH or Wnt signaling pathways. These approaches have significant drawbacks that limit their use in specific patient populations...
    Ressourcentyp:
    poster

  • The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.

    Keyword-Übereinstimmungen:
    ... thrombospondin-1 expression CL Doci, G Zhou and MW Lingen Thrombospondin-1 (TSP-1) is an endogenous inhibitor of ...
    ... angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 ...
    ... an antiangiogenic phenotype and suppresses tumor growth, in part through upregulation of TSP-1. Here ...
    ... machinery and specically interacts with TSP-1 mRNA through its 30 UTR. Reintroduction of NOL7 into SiHa ...
    ... cells increases luciferase expression through interaction with the TSP-1 30 UTR at both the mRNA and ...
    Schöpfer:
    Zhou, G., Doci, Colleen L., and Lingen, M.W.
    Beschreibung:
    Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there...
    Ressourcentyp:
    Article

  • A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives.

    Keyword-Übereinstimmungen:
    ... cartilage and bone repair, World Journal of Stem Cells, vol. 8, no. 1, pp. 112, 2016. [6] Z. Qi and Y.-G ...
    ... , Clinical Cancer Research, vol. 22, no. 1, pp. 96 106, 2016. [111] N. Ricard, D. Ciais, S. Levet et al ...
    ... College of Osteopathic Medicine 2016 A Survey of Strategies to Modulate the Bone Morphogenetic Protein ...
    ... Morphogenetic Protein (BMP) signaling pathway: current and future perspectives.'' Stem Cells International. 2016 ...
    ... @marian.edu. Hindawi Publishing Corporation Stem Cells International Volume 2016, Article ID 7290686, 15 ...
    Schöpfer:
    Brookshire, B, Rosen, V., and Lowery, Jonathan W.
    Beschreibung:
    Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-? family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical...
    Ressourcentyp:
    Article

  • Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells.

    Keyword-Übereinstimmungen:
    ... Hindawi Publishing Corporation Stem Cells International Volume 2016, Article ID 3753581, 7 pages ...
    ... http://dx.doi.org/10.1155/2016/3753581 Review Article Cell Fate and Differentiation of Bone Marrow ...
    ... Mesenchymal Stem Cells Shoichiro Kokabu,1,2 Jonathan W. Lowery,3 and Eijiro Jimi1 1 Division of Molecular ...
    ... Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, 2-6-1 Manazuru ...
    ... Received 18 March 2016; Accepted 5 May 2016 Academic Editor: Coralie Sengenes Copyright 2016 Shoichiro ...
    Schöpfer:
    Jimi, E., Kokabu, S, and Lowery, Jonathan W.
    Beschreibung:
    Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs) and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between...
    Ressourcentyp:
    Article