2 fold, either as a vector-expressed shRNA or as a transfected siRNA. We randomly mutagenized gFA2 to create a gFA2 variant sub-library. We screened this sub-library in primary FA fibroblasts and identified two gFA2 variants,...
Background: Zone based photodynamic therapy (PDT) is a promising treatment option for actinic keratosis, superficial basal cell carcinoma, and in-situ squamous cell carcinoma. PDT has similar cure rates to 5-fluorouracil and...
Background: The Taste receptor, type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient needs. TAS1R member 3 (TAS1R3) either recognizes amino acids such as glycine and...
Ote, Satoshi, King, Tyler, Lowery, Jonathan, and Rosen, Vickie
Beschreibung:
The Transforming Growth Factor-beta (TGFβ) superfamily is a large group of signaling molecules whose members play conserved roles in embryo specification, organogenesis, and tissue homeostasis. Structural considerations...
In the study, we are analyzing the human genome in order to determine patterns that may tell something about how DNA functions. Patterns require an explanation: it is highly improbable that they are random occurrence. These...
Lien, Savahanna, Wiley, Linda, Stepan, Rebecca, Voges, Margaret, Dunn, Ty, and Lecuyer-Koich, Anne
Beschreibung:
A comprehensive yet efficient evaluation of living kidney donor volunteers (LKDV) is key to a successful transplant program. Donor selection is complex and must balance donor medical suitability, compatibility issues and donor...
Polyphenolic compounds (anthocyanins, flavonoid glycosides) in berries prevent the initiation, promotion, and progression of carcinogenesis in rat’s digestive tract and esophagus, in part, via anti-inflammatory pathways....
Hypoxia is a critical stress that can affect the normal development of a mammal embryo. Normally, Hypoxia is buffered by the Utero-placental apparatus in human infants; however, prematurely delivered infants may encounter...
Lien, Savahanna, Matas, Arthur, Voges, Margaret, and Garvey, Cathy
Beschreibung:
Because of the benefits of preemptive living donor (LD) transplant, the desire for LD is rising. However, in the last decade, there has been no increase in LD in the U.S, possibility due to older donor candidate population...
Lien, Savahanna, Abt, Peter, Fayek, Sameh, Marsh, Christopher, and Dunn, Ty
Beschreibung:
While utilization of Kidney Paired Donation (KPD) continues to increase, the potential is not fully realized. We surveyed kidney transplant (KTX) professionals to evaluate perceptions of barriers and solutions to increasing KPD...