The Activin and BMP signaling pathways exert reciprocal effects on myogenesis and skeletal muscle regeneration after injury. Signal transduction in both pathways is mediated by ligand- induced activation of transcriptional...
Chlebek, Sylvia, Arthur, Jon, Newby, Jordan, and Lowery, Jonathan
Beschreibung:
Osteoporosis is a disease characterized by low bone mineral density due to the rate of bone resorption exceeding that of bone formation. Substantial evidence indicates the Bone Morphogenetic Protein (BMP) pathway promotes bone...
Farach-Carson Mary, Sharma, Karan, Kelly, Madison, Hum, Julia, Noonan, Megan, Yi, Xin, and Robling, Alexander
Beschreibung:
Mechanical loading is critical for bone remodeling. Voltage sensitive calcium channels (VSCCs) influence bone development and responses to loading. The α<sub>2</sub>δ<sub>1</sub> VSCC subunit regulates osteocyte...
Grice, Brian, Lei, Wei, Powell, Mackenzie, Boehm, Stephen, Greve, Katherynne, Elmendorf, Jeffrey, and Vigil, Daniel
Beschreibung:
Insulin resistance is associated with a high cumulative risk of AD and reduced cerebral glucose metabolism. New data suggest that increased hexosamine biosynthesis pathway (HBP) activity induces insulin resistance in adipose...
Ashack, Kurt, Martin, Anthony, and Aleshaki, Joseph
Beschreibung:
Cryoglobulinemia is a condition where immunoglobulins precipitate at temperatures < 37°C causing damage to blood vessels of the skin, joints, peripheral nervous system, and kidneys. Diagnosis is difficult due to various...
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such...
3D Visualization is a growing field in medicine. It is used for diagnosis, intervention design, and patient education. Medical students and physicians have little difficulty picturing a heart in their mind. Most physicians and...
It is estimated that more than 500,000 bone grafting surgeries occur yearly in the US to repair or replace defects caused by trauma, tumor resection, pathological degeneration and congenital malformations. Significant progress...
Hum, Julia M., Schoerning, Laura OMSII, Gorrell, Ruthann E., Newby, Jordan B., and Lowery, Jonathan W.
Beschreibung:
Osteoporosis, a disease of low bone mineral density, affects 10 million Americans and is a significant health problem and a considerable socioeconomic burden. Current treatments for osteoporosis have significant limitations,...
Wysocki, Laura, Shrack, Christopher, and Gallivan, Max
Beschreibung:
Palladium is often used in the synthesis of Active Pharmaceutical Ingredients (APIs), although it is toxic to ingest. As it is difficult to remove, it is imperative to develop optimal palladium sensors that can be utilized in...