INTRODUCTION: Two out of five U.S. citizens born after 2014 are expected to develop type 2 diabetes (T2D). T2D patients are at increased risk for fracture and impaired fracture healing, including: increased frequency of partial...
76% of the whole mouse genome. Of these, 840 genes met the t-test criteria, p<0.05. Canonical networks linked to EIF2 signaling, calcium ion signaling, and oxidative stress response were significantly enriched by the...
Thompson, William R., Kelly, Madison, Bender, Cecelia, Hum, Julia, Oberhelman, Forrest, and Young, Collin
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Voltage sensitive calcium channels (VSCCs) are key components in coordinating extracellular signaling that influence calcium (Ca2+) influx and subsequent downstream signaling in a variety of tissues including bone. Previous...
Tobin, Kirby, Hum, Julia, Oberhelman, Forrest, and Waite, Timothy
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Chronic Kidney Disease (CKD) affects approximately 1 in 10 Americans. Diabetic nephropathy is also associated with the development of chronic kidney disease-mineral bone disorder (CKD-MBD). CKD-MBD disrupts the normal...
Larsen, Bryan, Ogunbekun, Oladipupo, Schlehuser, Betsy, and Lowery, Jonathan
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Gardnerella vaginalis (GV) is associated with bacterial vaginosis (BV), a dysbiosis that predisposes to preterm labor and increased susceptibility to sexually transmitted infections. The potential role of cytokines elaborated...
Ristic, M., Rahman, R., Boncher, T., Gleason, S., Brinkman, H., Fein, A., Do, A., and Strom, David
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Development of new and highly tailored chemotherapeutic agents continues to be the mainstay for innovative clinical treatment of cancer. Peroxisome proliferator-activated receptors (PPARs), part of a nuclear hormone super...
Introduction: Bitter melon extract (BME) is known to inhibit breast cancer cells (MCF-7) proliferation. The PKC and ROK play critical roles in cell division, migration, and survival. However, the roles of protein kinase-c (PKC)...
Cavanaugh, Nicholas, Rossi, Nicholas, Aldoss, Osamah, El-Hattab, Ahmed, Reinking, Ben, Turek, Joseph, and Conway, Brian
Beschreibung:
Objectives: Arch branching has never been shown to influence recoarctation after extended end-to-end anastomosis via thoracotomy, yet in each study bovine arch identification is grossly underreported. This study aims to: 1)...
BACKGROUND: Non-Hodgkin Lymphoma (NHL) is a complicated disease that can result from a number of disease states in addition to typical cancerous processes. There are many treatment options for NHL. Typically, Rituximab, an...
The Bone Morphogenetic Protein (BMP) signaling pathway comprises the largest subdivision of the Transforming Growth Factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic development and postnatal...