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Neue Suche Stichwort Signal Transduction

  • The Role of BMP2 Signaling in the Skeleton.

    Schöpfer:
    Capelo, L.P., Chappuis, V., Kokabu, S, Lowery, Jonathan W., Rosen, V., Pazin, D., and Intini, G.
    Beschreibung:
    While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce...
    Ressourcentyp:
    Article

  • BMPR-II is Dispensable for Formation of the Limb Skeleton.

    Schöpfer:
    Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.
    Beschreibung:
    Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...
    Ressourcentyp:
    Article

  • BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

    Schöpfer:
    Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
    Beschreibung:
    Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
    Ressourcentyp:
    Article

  • Loss of BMPR2 Leads to High Bone Mass Due to Increased Osteoblast Activity

    Schöpfer:
    Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.
    Beschreibung:
    Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...
    Ressourcentyp:
    Article

  • Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer.

    Schöpfer:
    Doci, Colleen L., Gutkind, J. Silvio, and Sakurai, Atsuko
    Beschreibung:
    Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer....
    Ressourcentyp:
    Article

  • Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components.

    Schöpfer:
    Doci, Colleen L., Gutkind, J. Silvio, and Sakurai, Atsuko
    Beschreibung:
    Semaphorins are a family of membrane-bound and secreted type of proteins which were initially identified as chemorepulsive axon guidance molecules. Plexins and neuropilins are two major receptor families of semaphorins, and...
    Ressourcentyp:
    Article