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  • BMPR-II is Dispensable for Formation of the Limb Skeleton.

    Creator:
    Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.
    Description:
    Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...
    Type:
    Article

  • BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

    Creator:
    Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S
    Description:
    Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...
    Type:
    Article

  • Periosteal BMP2 Activity Drives Bone Graft Healing.

    Creator:
    Cox, K., Gamer, L., Bosshardt, D., Rosen, V., Lowery, Jonathan W., and Chappuis, V.
    Description:
    Bone graft incorporation depends on the orchestrated activation of numerous growth factors and cytokines in both the host and the graft. Prominent in this signaling cascade is BMP2. Although BMP2 is dispensable for bone...
    Type:
    Article