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Nova pesquisa Palavra-chave Activin Receptors

BMPR-II is Dispensable for Formation of the Limb Skeleton.

O Criador:

Cox, K., Tsuji, K., Gamer, L.W., Capelo, L.P., Rosen, V., Lowery, Jonathan W., and Beppu, H.

Descrição:

Initiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and...

Tipo:

Article
Allele-specific RNA Interference in FOP Silencing the FOP Gene

O Criador:

Rosen, V. and Lowery, Jonathan W.

Tipo:

Article
BMP3 Suppresses Osteoblast Differentiation of Bone Marrow Stromal Cells Via Interaction With Acvr2b.

O Criador:

Cox, K., Katagiri, T., Kunikazu, T., Econimedes, A., Gamer, L., Rosen, V., Lowery, Jonathan W., and Kokabu, S

Descrição:

Enhancing bone morphogenetic protein (BMP) signaling increases bone formation in a variety of settings that target bone repair. However, the role of BMP in the maintenance of adult bone mass is not well understood. Targeted...

Tipo:

Article
N-linked Glycosylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) Enhances Ligand Binding

O Criador:

Amich, J.M., Andonian, A., Rosen, V., and Lowery, Jonathan W.

Descrição:

The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate...

Tipo:

Article
Loss of BMPR2 Leads to High Bone Mass Due to Increased Osteoblast Activity

O Criador:

Ote, S., Cox, K., Baron, R., Intini, G., Salazar, V., Gamer, L., Lotinun, S., Rosen, V., and Lowery, Jonathan W.

Descrição:

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGF? signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors...

Tipo:

Article