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New Search Filtering by: Creator de Caestecker, M. ✖ Remove constraint Creator: de Caestecker, M.

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Effects of Different BMPR2 Mutations on Pulmonary Endothelial Cells from Patients with Hereditary Arterial Pulmonary Hypertension

Creator:

de Caestecker, M., Frump, A., and Lowery, Jonathan W.

Type:

Conference
Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

Creator:

Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.

Description:

Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...

Type:

Article
BMP Signaling in Vascular Development and Disease.

Creator:

Lowery, Jonathan W. and de Caestecker, M.

Description:

Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis...

Type:

Article
Bmp2 and Bmp4 Exert Opposing Effects in Hypoxic Pulmonary Hypertension

Creator:

Jones, M.T., Frank, D.B., Mortlock, D.P., de Caestecker, M., Chandler, R.L., Anderson, L.A., and Lowery, Jonathan W.

Description:

The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is...

Type:

Article
ID Family Protein Expression and Regulation in Hypoxic Pulmonary Hypertension

Creator:

Jones, M.T., Frump, A.L., diCarlo, G.E., Lowery, Jonathan W, Anderson, L.A., and de Caestecker, M.

Description:

Bone morphogenetic protein (BMP) signaling has been linked to the development of pulmonary hypertension (PH). Inhibitors of differentiation (ID) proteins (ID1-4) are a family of basic helix-loop-helix transcription factors that...

Type:

Article
BMP Signaling and Vascular Disease

Creator:

de Caestecker, M. and Lowery, Jonathan W.

Type:

Article
Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Creator:

Frump, A.L., Hamid, R., de Caestecker, M., Austin, E.D., and Lowery, Jonathan W.

Description:

More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2...

Type:

Article

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Work7

Article6
Conference1

de Caestecker, M.[remove]7
Lowery, Jonathan W.5
Anderson, L.A.2
Frank, D.B.2
Frump, A.L.2
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Bone Morphogenetic Protein Receptors3
Familial Primary Pulmonary Hypertension2
Mutation2
Pulmonary Circulation2
Alleles1
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English7

Current results range from 1/1/2008 to 8/1/2010

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Faculty Publications and Research - MUCOM7

Marian University7