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  • Therapeutic Discovery for Friedreich Ataxia Using Random shRNA Selection

    Schöpfer:
    Kaur, Avinash, Cotticelli, M., and Xia, Shujuan
    Beschreibung:
    2 fold, either as a vector-expressed shRNA or as a transfected siRNA. We randomly mutagenized gFA2 to create a gFA2 variant sub-library. We screened this sub-library in primary FA fibroblasts and identified two gFA2 variants,...
    Ressourcentyp:
    poster

  • Identification of p38 MAPK as a Novel Therapeutic Target for Friedreich’s Ataxia

    Schöpfer:
    Lin, Daniel, Tobias, John W., Cotticelli, M. Gracia, Ruff, Eric, Wang, Yongping, Xia, Shujuan, Wilson, Robert B., and Kaur, Avinash
    Beschreibung:
    Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC)...
    Ressourcentyp:
    Article