Obesity and metabolic dysfunction negatively impacts many tissues, including the skeleton. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase and key regulator of whole-body...
Patel, Sheel, Bello, Margaret , Warrick, Adam , Sankar, Uma, Robling, Alexander , Thompson, William, Shutter, Jennifer , Bellido, Teresita , and Williams, Justin
La description:
There is a need for anabolic therapies to treat degenerative bone
diseases. Mechanical loading stimulates anabolic and inhibits
catabolic pathways of bone leading to increased bone formation.
Osteocytes are the bone cell...