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Increased Susceptibility to Hypoxic Pulmonary Hypertension in Bmpr2 Mutant Mice is Associated with Endothelial Dysfunction in the Pulmonary Vasculature

Creator:

Brink, M., Frank, D.B., Reese, J., Lowery Jonathan W., Anderson, L., and de Caestecker, M.

Description:

Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary...

Type:

Article
Bmp2 and Bmp4 Exert Opposing Effects in Hypoxic Pulmonary Hypertension

Creator:

Jones, M.T., Frank, D.B., Mortlock, D.P., de Caestecker, M., Chandler, R.L., Anderson, L.A., and Lowery, Jonathan W.

Description:

The bone morphogenetic protein (BMP) type 2 receptor ligand, Bmp2, is upregulated in the peripheral pulmonary vasculature during hypoxia-induced pulmonary hypertension (PH). This contrasts with the expression of Bmp4, which is...

Type:

Article