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Nova pesquisa O Criador Doci, Colleen L.

  • Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

    O Criador:
    Mikelis, C., Zheng, Y., Zahra, F., Gutkind, J., Zabet-Moghaddam, M., Akwii, R., Doci, Colleen L., Tullar, P., and Sajib, S.
    Descrição:
    Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2 (Ang2) plays an important role in lymphatic vascular development and function and...
    Tipo:
    Article

  • Building STEM Equity and Identity in the Community

    O Criador:
    Ernstberger, Adrianna, Hall, Davyd, and Doci, Colleen L.
    Descrição:
    Numerous obstacles contribute to the underrepresentation of racial, ethnic, and gender groups in science and technology fields. However, addressing these barriers is complex and multifactorial. As part of their exploration of...
    Tipo:
    Poster

  • Making Plastic Polymers from Milk

    O Criador:
    Roessler, Meghann E.H., Contreras, Alisson, Doci, Colleen L., and Tesfa, Martina
    Descrição:
    Presented at the 2020 Celebrate Science Indiana Festival. Celebrate Science Indiana, Indiana’s Premier Science Festival, is a public event that demonstrates the importance of studying science and the joy of discovery, the...
    Tipo:
    Presentation and Other

  • Epidermal Loss of Gag Confers a Migratory and Differentiation Defect in Keratinocytes

    O Criador:
    Mikelis, Constantinos M., Gutkind, J. Slivio , Molinolo, Alfredo A. , Inoue, Asuka , Callejas-Valera, Juan Luis , Doci, Colleen L., Hansen, Karina K. , and Offermanns, Stefan
    Descrição:
    G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two...
    Tipo:
    Article

  • In Vitro Wound Healing Assays to Investigate Epidermal Migration.

    O Criador:
    Main, Kegan A., Mikelis, Constantinos M., and Doci, Colleen L.
    Descrição:
    Re-epithelialization after cutaneous injury is a complex and multifaceted process that incorporates numerous cellular components interacting in a myriad of pathways. One of the most crucial aspects of this process is the...
    Tipo:
    Article

  • Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

    O Criador:
    Tuz Zahra, Fatema, Kubota, Yoshiaki, Doci, Colleen L., Minchew, Shelby A., Cobos, Christopher, Gutkind, J. Silvio, Mikelis, Constantinos M., Zheng, Yi, Ichiyama, Yusuke, Sajib, Sanaullah, Tullar, Paul E., and Akwii, Racheal Grace
    Descrição:
    Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene...
    Tipo:
    Article

  • Identification and functional analysis of NOL7 nuclear and nucleolar localization signals.

    O Criador:
    Zhou, Guolin, Lingen, Mark W., and Doci, Colleen L.
    Descrição:
    BACKGROUND: NOL7 is a candidate tumor suppressor that localizes to a chromosomal region 6p23. This locus is frequently lost in a number of malignancies, and consistent loss of NOL7 through loss of heterozygosity and decreased...
    Tipo:
    Article

  • Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis.

    O Criador:
    Mankame, Tanmayi P., Zhou, Guolin, Wroblewski, Kristen, Lingen, Mark W., Doci, Colleen L., and Hasina, Rifat
    Descrição:
    Despite recent therapeutic advances, several factors, including field cancerization, have limited improvements in long-term survival for oral squamous cell carcinoma (OSCC). Therefore, comprehensive treatment plans must include...
    Tipo:
    Article

  • Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.

    O Criador:
    Doci, Colleen L., Langerman, Alexander, Kanteti, Rajani, Lingen,Mark W., Ostler, Kelly R., Onel,Kenan, Godley, Lucy A., Mankame, Tanmayi P., Best, Timothy, and Salgia, Ravi
    Descrição:
    NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into...
    Tipo:
    Article

  • Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer.

    O Criador:
    Doci, Colleen L., Gutkind, J. Silvio, and Sakurai, Atsuko
    Descrição:
    Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, and aberrant angiogenesis contributes to some of the most prevalent human diseases, including cancer....
    Tipo:
    Article